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  Specific white matter tissue microstructure changes associated with obesity

Kullmann, S., Callaghan, M. F., Heni, M., Weiskopf, N., Scheffler, K., Häring, H.-U., et al. (2016). Specific white matter tissue microstructure changes associated with obesity. NeuroImage, 125, 36-44. doi:10.1016/j.neuroimage.2015.10.006.

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 Urheber:
Kullmann, Stephanie1, 2, 3, Autor
Callaghan, Martina F.4, Autor
Heni, Martin1, 2, 5, Autor
Weiskopf, Nikolaus4, 6, Autor           
Scheffler, Klaus7, 8, Autor
Häring, Hans-Ulrich1, 2, 5, Autor
Fritsche, Andreas1, 2, 5, Autor
Veit, Ralf1, 2, 3, Autor
Preissl, Hubert1, 2, 5, 9, Autor
Affiliations:
1Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, Eberhard Karls University Tübingen, Germany, ou_persistent22              
2German Center for Diabetes Research, Tübingen, Germany, ou_persistent22              
3Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University Tübingen, Germany, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
5Department of Internal Medicine IV, Eberhard Karls University Tübingen, Germany, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
7Department of High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, ou_persistent22              
8Department of Biomedical Magnetic Resonance, University Hospital Tübingen, Germany, ou_persistent22              
9Department Pharmacy and Biochemistry, Faculty of Science, Eberhard Karls University Tübingen, Germany, ou_persistent22              

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Schlagwörter: DTI; Multi-parametric mapping; Obesity; Quantitative MRI
 Zusammenfassung: Obesity-related structural brain alterations point to a consistent reduction in gray matter with increasing body mass index (BMI) but changes in white matter have proven to be more complex and less conclusive. Hence, more recently diffusion tensor imaging (DTI) has been employed to investigate microstructural changes in white matter structure. Altogether, these studies have mostly shown a loss of white matter integrity with obesity-related factors in several brain regions. However, the variety of these obesity-related factors, including inflammation and dyslipidemia, resulted in competing influences on the DTI indices. To increase the specificity of DTI results, we explored specific brain tissue properties by combining DTI with quantitative multi-parameter mapping in lean, overweight and obese young adults. By means of multi-parameter mapping, white matter structures showed differences in MRI parameters consistent with reduced myelin, increased water and altered iron content with increasing BMI in the superior longitudinal fasciculus, anterior thalamic radiation, internal capsule and corpus callosum. BMI-related changes in DTI parameters revealed mainly alterations in mean and axial diffusivity with increasing BMI in the corticospinal tract, anterior thalamic radiation and superior longitudinal fasciculus. These alterations, including mainly fiber tracts linking limbic structures with prefrontal regions, could potentially promote accelerated aging in obese individuals leading to an increased risk for cognitive decline.

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Sprache(n): eng - English
 Datum: 2015-06-302015-10-042015-10-132016-01-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2015.10.006
PMID: 26458514
PMC: PMC4692452
Anderer: Epub 2015
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 125 Artikelnummer: - Start- / Endseite: 36 - 44 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166