English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Transfer of SABRE-derived hyperpolarization to spin-1/2 heteronuclei

Pravdivtsev, A. N., Yurkovskaya, A. V., Zimmermann, H., Vieth, H.-M., & Ivanov, K. L. (2015). Transfer of SABRE-derived hyperpolarization to spin-1/2 heteronuclei. RSC Advances, 5, 63615-63623. doi:10.1039/C5RA13808F.

Item is

Files

show Files
hide Files
:
RSCAdv_5_2015_63615.pdf (Any fulltext), 707KB
 
File Permalink:
-
Name:
RSCAdv_5_2015_63615.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:
Locator:
http://dx.doi.org/10.1039/C5RA13808F (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Pravdivtsev, Andrey N., Author
Yurkovskaya, Alexandra V., Author
Zimmermann, Herbert1, Author           
Vieth, Hans-Martin, Author
Ivanov, Konstantin L., Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

Content

show
hide
Free keywords: -
 Abstract: In this paper, we describe a method of hyper-polarizing “insensitive” Nuclear Magnetic Resonance (NMR) nuclei by exploiting the SABRE (Signal Amplification By Reversible Exchange) technique and transferring spin order from protons originating from parahydrogen. We demonstrate that hyperpolarization transfer is due to a coherent mechanism, which is operative at (i) very low magnetic field; (ii) geomagnetic field; (iii) high field in the presence of a suitable radiofrequency-excitation scheme. Experiments are performed using 15N-labelled pyridine as the SABRE substrate; NMR enhancements achieved for 15N nuclei are more than 1000 for free pyridine in solution and more than 20[thin space (1/6-em)]000 for pyridine bound to the SABRE complex. High-field SABRE experiments are particularly important for enhancing the sensitivity of NMR methods: they enable strong signal enhancements and avoid technically demanding field-cycling. Furthermore, such experiments use very low power for NMR excitation and make feasible continuous re-hyperpolarization of the substrate in high-field experiments: polarization can be quickly restored to the maximal level within only 15 seconds with the result that polarization levels stay constant over several hundred experiments. The techniques outlined are applicable to hyper-polarizing spin-1/2 hetero-nuclei, such as 13C, 19F, 31P, etc. Development of such methods opens new avenues in NMR spectroscopy and imaging, which were out of reach for sensitivity reasons.

Details

show
hide
Language(s): eng - English
 Dates: 2015-04-282015-07-202015-07-202015
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: RSC Advances
  Abbreviation : RSC Adv.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 63615 - 63623 Identifier: ISSN: 2046-2069
CoNE: https://pure.mpg.de/cone/journals/resource/2046-2069