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  Multi-center mapping of structural network alterations in autism

Valk, S. L., DiMartino, A., Milham, M., & Bernhardt, B. C. (2015). Multi-center mapping of structural network alterations in autism. Human Brain Mapping, 36(6), 2364-2373. doi:10.1002/hbm.22776.

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Genre: Zeitschriftenartikel

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externe Referenz:
https://doi.org/10.1002/hbm.22776 (Verlagsversion)
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OA-Status:
Grün

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 Urheber:
Valk, Sofie L.1, Autor           
DiMartino, Adriana2, Autor
Milham, M.ichael3, 4, Autor
Bernhardt, Boris C.1, 5, Autor           
Affiliations:
1Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
2Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience, New York University Child Study Center, NY, USA, ou_persistent22              
3Child Mind Institute, New York, NY, USA, ou_persistent22              
4Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
5McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              

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Schlagwörter: ASD; ABIDE; Neocortex; Connectivity; Medial PFC; Connectome
 Zusammenfassung: Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions primarily characterized by abnormalities in social cognition. Abundant previous functional MRI studies have shown atypical activity in networks encompassing medial prefrontal cortex (mPFC) and medial parietal regions corresponding to posterior cingulate cortex and precuneus (PCC/PCU). Conversely, studies assessing structural brain anomalies in ASD have been rather inconsistent. The current work evaluated whether structural changes in ASD can be reliability detected in a large multicenter dataset. Our comprehensive structural MRI framework encompassed cortical thickness mapping and structural covariance analysis based on three independent samples comprising individuals with ASD and controls (n = 220), selected from the Autism Brain Imaging Data Exchange open-access database. Surface-based analysis revealed increased cortical thickness in ASD relative to controls in mPFC and lateral prefrontal cortex. Clusters encompassing mPFC were embedded in altered inter-regional covariance networks, showing decreased covariance in ASD relative to controls primarily to PCC/PCU and inferior parietal regions. Cortical thickness increases and covariance reductions in ASD were consistent, yet of variable effect size, across the different sites evaluated and measurable both in children and adults. Our multisite study shows regional and network-level structural alterations in mPFC in ASD that, possibly, relate to atypical socio-cognitive functions in this condition.

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Sprache(n): eng - English
 Datum: 2014-09-042015-02-132015-02-252015-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hbm.22776
PMID: 25727858
PMC: PMC6129398
Anderer: Epub 2015
 Art des Abschluß: -

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Projektname : -
Grant ID : K01MH081191, K08MH092697, K23MH087770, P50MH060450, R01MH067924, R01MH080826, R01MH081218, R21MH084126
Förderprogramm : -
Förderorganisation : National Institute of Mental Health (NIMH)
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Förderorganisation : National Institutes of Health (NIH)
Projektname : -
Grant ID : F31DC010143, T32DC008553
Förderprogramm : -
Förderorganisation : National Institute on Deafness and Other Communication Disorders (NIDCD)
Projektname : -
Grant ID : R01NS034783
Förderprogramm : -
Förderorganisation : National Institute of Neurological Disorders and Stroke (NINDS)
Projektname : -
Grant ID : P50HD055748, R01HD065282
Förderprogramm : -
Förderorganisation : National Institute of Child Health and Human Development (NICHD)
Projektname : -
Grant ID : 04593
Förderprogramm : -
Förderorganisation : Autism Speaks
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Stavros Niarchos Foundation
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Grant ID : -
Förderprogramm : -
Förderorganisation : Leon Levy Foundation
Projektname : -
Grant ID : 1677
Förderprogramm : Mentor-based Predoctoral Fellowship
Förderorganisation : Autism Speaks
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : University of Utah Multidisciplinary Research Seed Grant
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Ben B. and Iris M. Margolis Foundation
Projektname : -
Grant ID : -
Förderprogramm : Jeanne Timmins Costello Award
Förderorganisation : Montreal Neurological Institute and Hospital
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Canadian Institutes of Health Research (CIHR)
Projektname : -
Grant ID : -
Förderprogramm : International Max Planck Research School Stipend, IMPRS NeuroCom
Förderorganisation : Max-Planck Society (MPG)

Quelle 1

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Titel: Human Brain Mapping
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 36 (6) Artikelnummer: - Start- / Endseite: 2364 - 2373 Identifikator: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686