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  Chemical synthesis of phosphatidylinositol mannoside glycans from Mycobacterium tuberculosis
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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-5F5F-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-5F60-C
Genre: Patent

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2156945.pdf (Publisher version), 2MB
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 Creators:
Seeberger, Peter H.1, Author              
Boonyarattanakalin, Siwarutt2, Author
Lepenies, Bernd3, Author              
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, escidoc:2040285              
2external, escidoc:persistent22              
3Bernd Lepenies, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, escidoc:1863298              

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 Abstract: The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM1 to PIM6) is reported. The invention relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the sulfhydryl group, a protein, a fluorescent probe, or a solid phase. The invention further relates to vaccines comprising the PIMs linked to a carrier protein or an antigen.

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 Dates: 2008-11-042010-05-14
 Publication Status: Published online
 Pages: -
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 Rev. Method: -
 Identifiers: Patent Application Nr.: EP20080019264
Patent Publication Nr.: WO2010051961
Patent Nr.: EP2414372
 Degree: -

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