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  Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

Arnlund, D., Johansson, L. C., Wickstrand, C., Barty, A., Williams, G. J., Malmerberg, E., et al. (2014). Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser. Nature methods, 11(9), 923-926. doi:10.1038/nmeth.3067.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-9673-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-A50C-0
Genre: Journal Article

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http://www.nature.com/nmeth/journal/v11/n9/pdf/nmeth.3067.pdf (Any fulltext)
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 Creators:
Arnlund, David, Author
Johansson, Linda C, Author
Wickstrand, Cecilia, Author
Barty, Anton, Author
Williams, Garth J, Author
Malmerberg, Erik, Author
Davidsson, Jan, Author
Milathianaki, Despina, Author
DePonte, Daniel P, Author
Shoeman, Robert L.1, Author           
Wang, Dingjie, Author
James, Daniel, Author
Katona, Gergely, Author
Westenhoff, Sebastian, Author
White, Thomas A, Author
Aquila, Andrew, Author
Bari, Sadia, Author
Berntsen, Peter, Author
Bogan, Mike, Author
van Driel, Tim Brandt, Author
Doak, R. Bruce1, Author           Kjær, Kasper Skov, AuthorFrank, Matthias, AuthorFromme, Raimund, AuthorGrotjohann, Ingo, AuthorHenning, Robert, AuthorHunter, Mark S, AuthorKirian, Richard A, AuthorKosheleva, Irina, AuthorKupitz, Christopher, AuthorLiang, Mengning, AuthorMartin, Andrew V, AuthorNielsen, Martin Meedom, AuthorMesserschmidt, Marc, AuthorSeibert, M Marvin, AuthorSjöhamn, Jennie, AuthorStellato, Francesco, AuthorWeierstall, Uwe, AuthorZatsepin, Nadia A, AuthorSpence, John C H, AuthorFromme, Petra, AuthorSchlichting, Ilme1, Author           Boutet, Sébastien, AuthorGroenhof, Gerrit, AuthorChapman, Henry N, AuthorNeutze, Richard, Author more..
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Free keywords: Molecular biophysics ; Biophysical methods ; Membrane proteins
 Abstract: We describe a method to measure ultrafast protein structural changes using time-resolved wide-angle X-ray scattering at an X-ray free-electron laser. We demonstrated this approach using multiphoton excitation of the Blastochloris viridis photosynthetic reaction center, observing an ultrafast global conformational change that arises within picoseconds and precedes the propagation of heat through the protein. This provides direct structural evidence for a 'protein quake': the hypothesis that proteins rapidly dissipate energy through quake-like structural motions.

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Language(s): eng - English
 Dates: 2014-03-202014-04-092014-08-102014-09-11
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: Other: 8046
DOI: 10.1038/nmeth.3067
URI: http://www.ncbi.nlm.nih.gov/pubmed/25108686
URI: http://www.nature.com/nmeth/journal/v11/n9/full/nmeth.3067.html
 Degree: -

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Title: Nature methods
  Other : Nature methods
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 11 (9) Sequence Number: - Start / End Page: 923 - 926 Identifier: ISSN: 1548-7091
CoNE: https://pure.mpg.de/cone/journals/resource/111088195279556