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Free keywords:
PATHOGENIC T(H)17 CELLS; MYELIN BASIC-PROTEIN; EPSTEIN-BARR-VIRUS;
MULTIPLE-SCLEROSIS; GUT MICROBIOTA; T-CELLS; DEMYELINATING DISEASE;
MOLECULAR MIMICRY; DENDRITIC CELLS; THEILERS VIRUSMultiple sclerosis; Central nervous system; Autoimmunity; Gut microbiota;
Abstract:
Not much is known about the initial events leading to the development of the central nervous system (CNS)-specific autoimmune disorder Multiple Sclerosis (MS). Environmental factors are suspected to trigger the pathogenic events in people with genetic disease susceptibility. Historically, many infectious microbes were linked to MS, but no infection has ever been demonstrated to be the cause of the disease. Recent emerging evidence from animal models of MS suggests a causal link with resident commensal bacteria. Microbial organisms may trigger the activation of CNS-specific, auto-aggressive lymphocytes either through molecular mimicry or via bystander activation. In addition, several gut microbial metabolites and bacterial products may interact with the immune system to modulate CNS autoimmunity. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
