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  Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3)-catalysed oxidation of cyclopropyl fatty acids.

Cryle, M., Hayes, P. Y., & De Voss, J. J. (2012). Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3)-catalysed oxidation of cyclopropyl fatty acids. Chemistry - A European Journal, 18(50), 15994-15999. doi:10.1002/chem.201203035.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-1147-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-1148-6
Genre: Journal Article
Alternative Title : Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3)-catalysed oxidation of cyclopropyl fatty acids.Oxidation of Cyclopropyl Fatty Acids

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ChemistEurJ_18_2012_15994.pdf (Any fulltext), 438KB
 
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 Creators:
Cryle, Max1, Author           
Hayes, Patricia Y., Author
De Voss, James J., Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Free keywords: carbocation; CYP102A1; cytochromes; enzyme catalysis; oxidation
 Abstract: The products of cytochrome P450BM3−catalysed oxidation of cyclopropyl−containing dodecanoic acids are consistent with the presence of a cationic reaction intermediate, which results in efficient dehydrogenation of the rearranged probes by the enzyme. These results highlight the importance of enzyme−substrate complementarity, with a cationic intermediate occurring only when the probes used begin to diverge from ideal substrates for this enzyme. This also aids in reconciling literature reports supporting the presence of cationic intermediates with certain cytochrome P450 enzyme/substrate pairs

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Language(s): eng - English
 Dates: 2012-08-272012-10-292012-10-292012-12-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664314
DOI: 10.1002/chem.201203035
URI: http://www.ncbi.nlm.nih.gov/pubmed/23109039
URI: http://onlinelibrary.wiley.com/doi/10.1002/chem.201203035/full
URI: http://onlinelibrary.wiley.com/doi/10.1002/chem.201203035/pdf
Other: 7881
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Title: Chemistry - A European Journal
  Other : Chem. Eur. J.
Source Genre: Journal
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Publ. Info: Weinheim, Germany : VCH Verlagsgesellschaft
Pages: - Volume / Issue: 18 (50) Sequence Number: - Start / End Page: 15994 - 15999 Identifier: ISSN: 0947-6539
CoNE: https://pure.mpg.de/cone/journals/resource/954926979058