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Abstract:
Gene transcription in the nucleus of eukaryotic cells is
carried out by three related multisubunit RNA polymerases,
Pol I, Pol II and Pol III. Although the structure
and function of the polymerases have been studied
extensively, little is known about their biogenesis and
their transport from the cytoplasm (where the subunits
are synthesized) to the nucleus. Recent studies have
revealed polymerase assembly intermediates and putative
assembly factors, as well as factors required for Pol II
nuclear import. In this review, we integrate the available
data into a model of Pol II biogenesis that provides a
framework for future analysis of the biogenesis of all
RNA polymerases.
