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  Measurement of genome-wide RNA synthesis and decay rates with Dynamic Transcriptome Analysis (DTA)

Schwalb, B., Schulz, D., Sun, M., Zacher, B., Dümcke, S., Martin, D. E., et al. (2012). Measurement of genome-wide RNA synthesis and decay rates with Dynamic Transcriptome Analysis (DTA). Bioinformatics, 28(6), 884-885. doi:10.1093/bioinformatics/bts052.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0015-7C76-B Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-3609-B
Genre: Journal Article

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http://bioinformatics.oxfordjournals.org/content/28/6/884.full.pdf (Publisher version)
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Schwalb, B., Author
Schulz, D., Author
Sun, M., Author
Zacher, B., Author
Dümcke, S., Author
Martin, D. E., Author
Cramer, P.1, Author           
Tresch, A., Author
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1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: Standard transcriptomics measures total cellular RNA levels. Our understanding of gene regulation would be greatly improved if we could measure RNA synthesis and decay rates on a genome-wide level. To that end, the Dynamic Transcriptome Analysis (DTA) method has been developed. DTA combines metabolic RNA labeling with standard transcriptomics to measure RNA synthesis and decay rates in a precise and non-perturbing manner. Here, we present the open source R/Bioconductor software package DTA. It implements all required bioinformatics steps that allow the accurate absolute quantification and comparison of RNA turnover.

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Language(s): eng - English
 Dates: 2012-01-28
 Publication Status: Published online
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 Identifiers: DOI: 10.1093/bioinformatics/bts052
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Title: Bioinformatics
Source Genre: Journal
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Pages: - Volume / Issue: 28 (6) Sequence Number: - Start / End Page: 884 - 885 Identifier: -