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  A movie of RNA polymerase II transcription

Cheung, A. C. M., & Cramer, P. (2012). A movie of RNA polymerase II transcription. Cell, 149(7), 1431-1437. doi:10.1016/j.cell.2012.06.006.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0015-3E91-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-DBDC-E
Genre: Journal Article

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1933063.pdf (Publisher version), 752KB
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 Creators:
Cheung, A. C. M., Author
Cramer, P.1, Author           
Affiliations:
1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

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Language(s): eng - English
 Dates: 2012-06-22
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cell.2012.06.006
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 149 (7) Sequence Number: - Start / End Page: 1431 - 1437 Identifier: -