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  The CONNECT project: Combining macro- and micro-structure

Assaf, Y., Alexander, D. C., Jones, D. K., Bizzi, A., Behrens, T. E., Clark, C. A., et al. (2013). The CONNECT project: Combining macro- and micro-structure. NeuroImage, 80, 273-282. doi:10.1016/j.neuroimage.2013.05.055.

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Assaf, Yaniv, Autor
Alexander, Daniel C., Autor
Jones, Derek K., Autor
Bizzi, Albero, Autor
Behrens, Tim E.J., Autor
Clark, Chris A., Autor
Cohen, Yoram, Autor
Dyrby, Tim B., Autor
Huppi, Petra S., Autor
Knösche, Thomas R.1, Autor           
LeBihan, Denis, Autor
Parker, Geoff J.M., Autor
Poupon, Cyril, Autor
Anaby, Debbie2, Autor
Anwander, Alfred1, 2, Autor           
Bar, Leah2, Autor
Barazany, Daniel2, Autor
Blumenfeld-Katzir, Tamar2, Autor
De-Santis, Silvia2, Autor
Duclap, Delphine2, Autor
Figini, Matteo2, AutorFischi, Elda2, AutorGuevara, Pamela2, AutorHubbard, Penny2, AutorHofstetter, Shir2, AutorJbabdi, Saad2, AutorKunz, Nicolas2, AutorLazeyras, Francois2, AutorLebois, Alice2, AutorLiptrot, Matthew G.2, AutorLundell, Henrik2, AutorMangin, Jean-François2, AutorMoreno-Dominguez, David1, 2, Autor           Morozov, Darya2, AutorSchreiber, Jan1, 2, Autor           Seunarine, Kiran2, AutorNava, Simone2, AutorPoupon, Cyril2, AutorRiffert, Till1, 2, Autor           Sasson, Efrat2, AutorSchmitt, Benoit2, AutorShemesh, Noam2, AutorSotiropoulos, Stam N.2, AutorTavora, Ido2, AutorZhang, Hui (Gary)2, AutorZhou, Feng-Lei2, Autor mehr..
Affiliations:
1Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
2CONNECT Consortium (alphabetically ordered), ou_persistent22              

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 Zusammenfassung: In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.

The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

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Sprache(n): eng - English
 Datum: 2013-05-082013-05-282013-10-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2013.05.055
PMID: 23727318
Anderer: Epub 2013
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 80 Artikelnummer: - Start- / Endseite: 273 - 282 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166