Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.

Juranek, J. K., Mukherjee, K., Siddiqui, T. J., Kaplan, B. J., Li, J. Y., Ahnert-Hilger, G., et al. (2013). Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat. Acta Histochemica, 116(6), 616-625. doi:10.1016/j.acthis.2013.01.003.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
1835167.pdf (Verlagsversion), 4MB
 
Datei-Permalink:
-
Name:
1835167.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (UNKNOWN id 303; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Urheber

einblenden:
ausblenden:
 Urheber:
Juranek, J. K., Autor
Mukherjee , K., Autor
Siddiqui, T. J.1, Autor           
Kaplan, B. J., Autor
Li , J. Y., Autor
Ahnert-Hilger, G., Autor
Jahn, R.1, Autor           
Calka, J., Autor
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Active zone; Active zone proteins; Rat; Cerebellar cortex; Neurogenesis; Synaptogenesis; Immunofluorescence
 Zusammenfassung: Signal transduction and neurotransmitter release in the vertebrate central nervous system are confined to the structurally complex presynaptic electron dense projections called “active zones.” Although the nature of these projections remains a mystery, genetic and biochemical work has provided evidence for the active zone (AZ) associated proteins i.e. Piccolo/Aczonin, Bassoon, RIM1/Unc10, Munc13/Unc13, Liprin-α/SYD2/Dliprin and ELKS/CAST/BRP and their specific molecular functions. It still remains unclear, however, what their precise contribution is to the AZ assembly. In our project, we studied in Wistar rats the temporal and spatial distribution of AZ proteins and their colocalization with Synaptophysin in the developing cerebellar cortex at key stages of cerebellum neurogenesis. Our study demonstrated that AZ proteins were already present at the very early stages of cerebellar neurogenesis and exhibited distinct spatial and temporal variations in immunoexpression throughout the course of the study. Colocalization analysis revealed that the colocalization pattern was time-dependent and different for each studied protein. The highest collective mean percentage of colocalization (>85%) was observed at postnatal day (PD) 5, followed by PD10 (>83%) and PD15 (>80%). The findings of our study shed light on AZ protein immunoexpression changes during cerebellar cortex neurogenesis and help frame a hypothetical model of AZ assembly.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2013-02-212013-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.acthis.2013.01.003
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Acta Histochemica
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 116 (6) Artikelnummer: - Start- / Endseite: 616 - 625 Identifikator: -