Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.

Barclay, J. L., Shostak, A., Leliavski, A., Tsang, A. H., Jöhren, O., Müller-Fielitz, H., et al. (2013). High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. American Journal of Physiology-Endocrinology and Metabolism, 304(10), E1053-E1063. doi:10.1152/ajpendo.00512.2012.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
1795436l.pdf (Verlagsversion), 468KB
 
Datei-Permalink:
-
Name:
1795436l.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (UNKNOWN id 303; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Barclay, J. L.1, Autor           
Shostak, A.1, Autor           
Leliavski, A.1, Autor           
Tsang, A. H.1, Autor           
Jöhren, O., Autor
Müller-Fielitz, H., Autor
Landgraf, D.1, Autor           
Naujokat, N.1, Autor           
van der Horst, G., Autor
Oster, H.1, Autor           
Affiliations:
1Research Group of Circadian Rhythms, MPI for biophysical chemistry, Max Planck Society, ou_578594              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Perturbation of circadian rhythmicity in mammals, either by environmental influences such as shiftwork or by genetic manipulation, has been associated with metabolic disturbance and the development of obesity and diabetes. Circadian clocks are based on transcriptional/translational feedback loops, comprising positive and negative components. Whereas the metabolic effects of deletion of the positive arm of the clock gene machinery, as in Clock- or Bmal1-deficient mice, have been well characterized, inactivation of Period genes (Per1-3) as components of the negative arm have more complex, sometimes contradictory effects on energy homeostasis. The CRYPTOCHROMEs are critical interaction partners of PERs, and simultaneous deletion of Cry1 and -2 results in behavioral and molecular circadian arrhythmicity. We show that, when challenged with a high-fat diet, Cry1/2(-/-) mice rapidly gain weight and surpass that of wild-type mice, despite displaying hypophagia. Transcript analysis of white adipose tissue reveals up-regulated expression of lipogenic genes, many of which are insulin targets. High-fat diet-induced hyperinsulinemia, as a result of potentiated insulin secretion, coupled with selective insulin sensitivity in adipose tissue of Cry1/2(-/-) mice, correlates with increased lipid uptake. Collectively, these data indicate that Cry deficiency results in an increased vulnerability to high-fat diet-induced obesity that might be mediated by increased insulin secretion and lipid storage in adipose tissues.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2013-03-262013-05-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1152/ajpendo.00512.2012
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: American Journal of Physiology-Endocrinology and Metabolism
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 304 (10) Artikelnummer: - Start- / Endseite: E1053 - E1063 Identifikator: -