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  Matrix-algebra-based calculations of the time evolution of the binary spin-bath model for magnetization transfer

Müller, D., Pampel, A., & Möller, H. E. (2013). Matrix-algebra-based calculations of the time evolution of the binary spin-bath model for magnetization transfer. Journal of Magnetic Resonance, 230, 88-97. doi:10.1016/j.jmr.2013.01.013.

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 Urheber:
Müller, Dirk1, Autor           
Pampel, André1, Autor           
Möller, Harald E.1, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Schlagwörter: Bloch–McConnell equations; Continuous-wave saturation; Matrix algebra; Polynomial interpolation; Pulsed saturation; Quantitative magnetization-transfer imaging
 Zusammenfassung: Quantification of magnetization-transfer (MT) experiments are typically based on the assumption of the binary spin-bath model. This model allows for the extraction of up to six parameters (relative pool sizes, relaxation times, and exchange rate constants) for the characterization of macromolecules, which are coupled via exchange processes to the water in tissues. Here, an approach is presented for estimating MT parameters acquired with arbitrary saturation schemes and imaging pulse sequences. It uses matrix algebra to solve the Bloch–McConnell equations without unwarranted simplifications, such as assuming steady-state conditions for pulsed saturation schemes or neglecting imaging pulses. The algorithm achieves sufficient efficiency for voxel-by-voxel MT parameter estimations by using a polynomial interpolation technique. Simulations, as well as experiments in agar gels with continuous-wave and pulsed MT preparation, were performed for validation and for assessing approximations in previous modeling approaches. In vivo experiments in the normal human brain yielded results that were consistent with published data.

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Sprache(n): eng - English
 Datum: 2013-01-212012-05-232013-02-092013-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.jmr.2013.01.013
PMID: 23454578
Anderer: Epub 2013
 Art des Abschluß: -

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Titel: Journal of Magnetic Resonance
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: San Diego [etc.] : Academic Press
Seiten: - Band / Heft: 230 Artikelnummer: - Start- / Endseite: 88 - 97 Identifikator: ISSN: 0022-2364
CoNE: https://pure.mpg.de/cone/journals/resource/954922651175_1