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  Metabolic network structure determines key aspects of functionality and regulation

Stelling, J., Klamt, S., Bettenbrock, K., Schuster, S., & Gilles, E. D. (2002). Metabolic network structure determines key aspects of functionality and regulation. Nature, 420(6912), 190-193. doi:10.1038/nature01166.

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Genre: Zeitschriftenartikel
Alternativer Titel : Nature

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Stelling, J.1, Autor           
Klamt, S.1, Autor           
Bettenbrock, K.1, Autor           
Schuster, S.2, Autor
Gilles, E. D.1, Autor           
Affiliations:
1Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              
2Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany, ou_persistent22              

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 Zusammenfassung: The relationship between structure, function and regulation in complex cellular networks is a still largely open question(1- 3). Systems biology aims to explain this relationship by combining experimental and theoretical approaches(4). Current theories have various strengths and shortcomings in providing an integrated, predictive description of cellular networks. Specifically, dynamic mathematical modelling of large-scale networks meets difficulties because the necessary mechanistic detail and kinetic parameters are rarely available. In contrast, structure-oriented analyses only require network topology, which is well known in many cases. Previous approaches of this type focus on network robustness(5) or metabolic phenotype(2,6), but do not give predictions on cellular regulation. Here, we devise a theoretical method for simultaneously predicting key aspects of network functionality, robustness and gene regulation from network structure alone. This is achieved by determining and analysing the non- decomposable pathways able to operate coherently at steady state (elementary flux modes). We use the example of Escherichia coli central metabolism to illustrate the method. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. [accessed 2013 June 13th]

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Sprache(n): eng - English
 Datum: 2002
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/nature01166
eDoc: 13791
 Art des Abschluß: -

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Titel: Nature
  Alternativer Titel : Nature
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 420 (6912) Artikelnummer: - Start- / Endseite: 190 - 193 Identifikator: ISSN: 0028-0836