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  Enantiomeric 3-Chloromandelic Acid System: Binary Melting Point Phase Diagram, Ternary Solubility Phase Diagrams and Polymorphism

Le Minh, T., von Langermann, J., Lorenz, H., & Seidel-Morgenstern, A. (2010). Enantiomeric 3-Chloromandelic Acid System: Binary Melting Point Phase Diagram, Ternary Solubility Phase Diagrams and Polymorphism. Journal of Pharmaceutical Sciences, 99(9), 4084-4095. doi:10.1002/jps.22234.

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Le Minh, T.1, 2, Autor           
von Langermann, J.1, Autor           
Lorenz, H.1, Autor           
Seidel-Morgenstern, A.1, 3, Autor           
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2International Max Planck Research School (IMPRS), ou_1738143              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Schlagwörter: 3-chloromandelic acid; racemic compound; binary and ternary phase diagrams; polymorphism; X-ray diffraction; calorimetry (DSC); chirality; crystallization
 Zusammenfassung: A systematic study of binary melting point and ternary solubility phase diagrams of the enantiomeric 3-chloromandelic acid (3-ClMA) system was performed under consideration of polymorphism. The melting point phase diagram was measured by means of thermal analysis, that is, using heat-flux differential scanning calorimetry (DSC). The results reveal that 3-ClMA belongs to the racemic compound-forming systems. Polymorphism was found for both the enantiomer and the racemate as confirmed by X-ray powder diffraction analysis. The ternary solubility phase diagram of 3-ClMA in water was determined between 5 and 50°C by the classical isothermal technique. The solubilities of the pure enantiomers are extremely temperature-dependent. The solid–liquid equilibria of racemic 3-ClMA are not trivial due to the existence of polymorphism. The eutectic composition in the chiral system changes as a function of temperature. Further, solubility data in the alternative solvent toluene are also presented. copyright 2010 Wiley-Liss, Inc. and the American Pharmacists Association [accessed September 30th 2010]

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Sprache(n): eng - English
 Datum: 2010
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 476363
Anderer: 47/10
DOI: 10.1002/jps.22234
 Art des Abschluß: -

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Titel: Journal of Pharmaceutical Sciences
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 99 (9) Artikelnummer: - Start- / Endseite: 4084 - 4095 Identifikator: -