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  The binary phase diagram of propranolol hydrochloride and crystallization-based enantioseparation

Polenske, D., Lorenz, H., & Seidel-Morgenstern, A. (2010). The binary phase diagram of propranolol hydrochloride and crystallization-based enantioseparation. Journal of Pharmaceutical Sciences, 99(4), 1762-1773. doi:10.1002/jps.21943.

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Polenske, D.1, Autor           
Lorenz, H.1, Autor           
Seidel-Morgenstern, A.1, 2, Autor           
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Schlagwörter: conglomerate • racemic compound • binary phase diagram • solid solutions • polymorphism • thermal analysis • calorimetry (DSC) • X-ray powder diffraction • separation science • chiral resolution • crystallization • propranolol hydrochloride
 Zusammenfassung: Inconsistent results were reported for the solid-state nature of the racemic species of the pharmaceutical relevant compound propranolol hydrochloride. In this work the binary phase diagram of the propranolol hydrochloride enantiomers is studied. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and high performance liquid chromatography (HPLC) were used as analytical methods. The type of the racemic species, the presence and extent of partial solid solutions and the stability regions of polymorphic forms in the system were investigated. The identified binary phase diagram is sketched. Finally, the feasibility of crystallization-based resolution is discussed. Copyright © 2009 Wiley-Liss, Inc., A Wiley Company. [accessed November 25, 2009]

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Sprache(n): eng - English
 Datum: 2010
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 437031
DOI: 10.1002/jps.21943
 Art des Abschluß: -

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Titel: Journal of Pharmaceutical Sciences
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 99 (4) Artikelnummer: - Start- / Endseite: 1762 - 1773 Identifikator: -