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  Multi-stage crystallization for resolution of enantiomeric mixtures in a solid solution forming system

Balawejder, M., Galan, K., Elsner, M. P., Seidel-Morgenstern, A., Piatkowski, W., & Antos, D. (2011). Multi-stage crystallization for resolution of enantiomeric mixtures in a solid solution forming system. Chemical Engineering Science, 66(22), 5638-5647. doi:10.1016/j.ces.2011.07.051.

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 Urheber:
Balawejder, Maciej1, Autor
Galan, Kamila2, Autor           
Elsner, Martin Peter2, Autor           
Seidel-Morgenstern, Andreas2, 3, Autor           
Piatkowski, Wojciech4, Autor
Antos, Dorota4, Autor           
Affiliations:
1University of Rzeszów,,Rzeszów, Poland, ou_persistent22              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
4Rzeszow Univ Technol, Rzeszow, Poland, ou_persistent22              

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Schlagwörter: Crystallisation; Citalopram; Downstream processing; Enantiomers; Phase equilibria; Separations
 Zusammenfassung: A systematic procedure for synthesizing the multistage crystallization process was developed for resolution of enantiomeric mixtures involving solid solutions in the crystalline phase. The model compound investigated was citalopram oxalate, which revealed a complete solid solution in the solid phase. The counter-current multi-stage batch crystallization was suggested to isolate the target enantiomer from enantiomerically enriched mixtures. The solid-liquid equilibria in the presence of a solvent and the distribution diagrams were quantified and used in designing the crystallization process and defining adequate processing conditions. Different flowsheet schemes were considered and compared with respect to the process performance. The design procedure was verified by the experimental separation of enantiomeric mixtures of citalopram. Copyright © 2011 Elsevier Ltd All rights reserved. [accessed August 31st 2011]

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Sprache(n): eng - English
 Datum: 2011
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 570980
DOI: 10.1016/j.ces.2011.07.051
 Art des Abschluß: -

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Titel: Chemical Engineering Science
  Andere : Chem. Eng. Sci.
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: Amsterdam : Pergamon
Seiten: - Band / Heft: 66 (22) Artikelnummer: - Start- / Endseite: 5638 - 5647 Identifikator: ISSN: 0009-2509
CoNE: https://pure.mpg.de/cone/journals/resource/954925389239