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  Whole-genome sequencing of multiple Arabidopsis thaliana populations

Cao, J., Schneeberger, K., Ossowski, S., Günther, T., Bender, S., Fitz, J., et al. (2011). Whole-genome sequencing of multiple Arabidopsis thaliana populations. Nature Genetics, 43(10), 956-963. doi:10.1038/ng.911.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-4C34-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0BA5-2
Genre: Journal Article

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Cao, J., Author
Schneeberger, K., Author
Ossowski, S., Author
Günther, T., Author
Bender, S., Author
Fitz, J., Author
Koenig, D., Author
Lanz, C., Author
Stegle, O.1, Author              
Lippert, C.2, Author
Wang, X.3, Author              
Ott, F., Author
Müller, J.4, Author              
Alonso-Blanco, C., Author
Borgwardt, K.1, 5, Author              
Schmid, K. J., Author
Weigel, D.6, Author              
Affiliations:
1Research Group Machine Learning and Computational Biology, Max Planck Institute for Intelligent Systems, Max Planck Society, escidoc:1497664              
2Max Planck Society, escidoc:persistent13              
3Former Dept. Theory of Mesoscopic Phenomena, Max Planck Institute for Intelligent Systems, Max Planck Society, escidoc:1497656              
4Dept. Theory of Inhomogeneous Condensed Matter, Max Planck Institute for Intelligent Systems, Max Planck Society, escidoc:1497643              
5Dept. Empirical Inference, Max Planck Institute for Intelligent Systems, Max Planck Society, escidoc:1497647              
6Dept. Metastable and Low-Dimensional Materials, Max Planck Institute for Intelligent Systems, Max Planck Society, escidoc:1497645              

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Free keywords: MPI für Intelligente Systeme; Abt. Schölkopf;
 Abstract: The plant Arabidopsis thaliana occurs naturally in many different habitats throughout Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse environments, a 1001 Genomes Project to sequence geographically diverse A. thaliana strains has been initiated. Here we present the first phase of this project, based on population-scale sequencing of 80 strains drawn from eight regions throughout the species' native range. We describe the majority of common small-scale polymorphisms as well as many larger insertions and deletions in the A. thaliana pan-genome, their effects on gene function, and the patterns of local and global linkage among these variants. The action of processes other than spontaneous mutation is identified by comparing the spectrum of mutations that have accumulated since A. thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations.

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 Dates: 2011-10-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 596134
URI: http://www.kyb.tuebingen.mpg.de/
Other: CaoSOGBFKLSLWOMABSW2012
DOI: 10.1038/ng.911
 Degree: -

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Title: Nature Genetics
Source Genre: Journal
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Publ. Info: -
Pages: -956 Volume / Issue: 43 (10) Sequence Number: - Start / End Page: 956 - 963 Identifier: -