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  Time-resolved protein nanocrystallography using an X-ray free-electron laser

Aquila, A., Hunter, M. S., Doak, R. B., Kirian, R. A., Fromme, P., White, T. A., et al. (2012). Time-resolved protein nanocrystallography using an X-ray free-electron laser. Optics Express, 20(3), 2706-2716.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-A26C-4 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-A26D-2
Genre: Zeitschriftenartikel

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http://dx.doi.org/10.1364/OE.20.002706 (Verlagsversion)
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 Urheber:
Aquila, Andrew1, Autor
Hunter, Mark S.1, Autor
Doak, R. Bruce1, Autor
Kirian, Richard A.1, Autor
Fromme, Petra1, Autor
White, Thomas A.1, Autor
Andreasson, Jakob1, Autor
Arnlund, David1, Autor
Bajt, Saša1, Autor
Barends, Thomas R. M.1, Autor
Barthelmess, Miriam1, Autor
Bogan, Michael J.1, Autor
Bostedt, Christoph1, Autor
Bottin, Hervé1, Autor
Bozek, John D.1, Autor
Caleman, Carl1, Autor
Coppola, Nicola1, Autor
Davidsson, Jan1, Autor
DePonte, Daniel P.1, Autor
Elser, Veit1, Autor
Epp, S. W.2, Autor           Erk, Benjamin1, AutorFleckenstein, Holger1, AutorFoucar, Lutz1, AutorFrank, Matthias1, AutorFromme, Raimund1, AutorGraafsma, Heinz1, AutorGrotjohann, Ingo1, AutorGumprecht, Lars1, AutorHajdu, Janos1, AutorHampton, Christina Y.1, AutorHartmann, Andreas1, AutorHartmann, Robert1, AutorHau-Riege, Stefan1, AutorHauser, Günter1, AutorHirsemann, Helmut1, AutorHoll, Peter1, AutorHolton, James M.1, AutorHömke, André1, AutorJohansson, Linda1, AutorKimmel, Nils1, AutorKassemeyer, Stephan1, AutorKrasniqi, Faton1, AutorKühnel, Kai-Uwe2, Autor           Liang, Mengning1, AutorLomb, Lukas1, AutorMalmerberg, Erik1, AutorMarchesini, Stefano1, AutorMartin, Andrew V.1, AutorMaia, Filipe R.N.C.1, AutorMesserschmidt, Marc1, AutorNass, Karol1, AutorReich, Christian1, AutorNeutze, Richard1, AutorRolles, Daniel1, AutorRudek, Benedikt2, Autor           Rudenko, Artem2, Autor           Schlichting, Ilme1, AutorSchmidt, Carlo1, AutorSchmidt, Kevin E.1, AutorSchulz, Joachim1, AutorSeibert, M. Marvin1, AutorShoeman, Robert L.1, AutorSierra, Raymond1, AutorSoltau, Heike1, AutorStarodub, Dmitri1, AutorStellato, Francesco1, AutorStern, Stephan1, AutorStrüder, Lothar1, Autor           Timneanu, Nicusor1, AutorUllrich, Joachim2, Autor           Wang, Xiaoyu1, AutorWilliams, Garth J.1, AutorWeidenspointner, Georg1, Autor           Weierstall, Uwe1, AutorWunderer, Cornelia1, AutorBarty, Anton1, AutorSpence, John C. H.1, AutorChapman, Henry N.1, Autor mehr..
Affiliations:
1Center for Free-Electron Laser Science, DESY, Notkestraße 85, 22607 Hamburg, Germany; Photon Science, DESY, Notkestraße 85, 22607 Hamburg, Germany; Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604 USA; Department of Physics, Arizona State University, Tempe, Arizona 85287 USA; Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden; Department of Chemistry, Biochemistry, and Biophysics, Göteborg University, SE-405 30 Göteborg, Sweden; Max Planck Advanced Study Group, Center for Free Electron Laser Science; (CFEL), Notkestraße 85, 22607 Hamburg, Germany; Max-Planck-Institut für medizinische Forschung, Jahnstr. 29, 69120 Heidelberg, Germany; PULSE Institute and SLAC National Accelerator Laboratory, 2575 Sand Hill Road. Menlo Park, CA 94025, USA; LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road. Menlo Park, CA 94025, USA 11CEA, Institut de Biologie et de Technologies de Saclay, 91191 Gif-sur-Yvette Cedex, France; European XFEL GmbH, Albert-Einstein-Ring 19, 22761 Hamburg, Germany; Department of Physics, Cornell University, Ithaca, New York 14853 USA;; Lawrence Livermore National Laboratory, 7000 East Avenue, Mail Stop L-211, Livermore, CA 94551, USA; PNSensor GmbH, Otto-Hahn-Ring 6, 81739 München, Germany; Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany; Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA 19University of Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany; Max-Planck-Institut für extraterrestrische Physik, Giessenbachstraße, 85741 Garching, Germany, ou_159890              
2Division Prof. Dr. Joachim H. Ullrich, MPI for Nuclear Physics, Max Planck Society, ou_904547              

Inhalt

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 Zusammenfassung: We demonstrate the use of an X-ray free electron laser synchronized with an optical pump laser to obtain X-ray diffraction snapshots from the photoactivated states of large membrane protein complexes in the form of nanocrystals flowing in a liquid jet. Light-induced changes of Photosystem I-Ferredoxin co-crystals were observed at time delays of 5 to 10 µs after excitation. The result correlates with the microsecond kinetics of electron transfer from Photosystem I to ferredoxin. The undocking process that follows the electron transfer leads to large rearrangements in the crystals that will terminally lead to the disintegration of the crystals. We describe the experimental setup and obtain the first time-resolved femtosecond serial X-ray crystallography results from an irreversible photo-chemical reaction at the Linac Coherent Light Source. This technique opens the door to time-resolved structural studies of reaction dynamics in biological systems

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Sprache(n): eng - English
 Datum: 2012-01-30
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: Anderer: null
 Art des Abschluß: -

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Quelle 1

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Titel: Optics Express
  Kurztitel : Opt. Express
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, DC : Optical Society of America
Seiten: - Band / Heft: 20 (3) Artikelnummer: - Start- / Endseite: 2706 - 2716 Identifikator: ISSN: 1094-4087