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  A major susceptibility locus for leprosy in India maps to chromosome 10p13 [Letter]

Siddiqui, M. R., Meisner, S., Tosh, K., Balakrishnan, K., Ghei, S., Fisher, S. E., et al. (2001). A major susceptibility locus for leprosy in India maps to chromosome 10p13 [Letter]. Nature Genetics, 27, 439-441. doi:10.1038/86958.

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Siddiqui_A_Major_Susceptibility_Locus_Nature_Genet_2001.pdf (Publisher version), 48KB
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Siddiqui, M. Ruby, Author
Meisner, Sarah, Author
Tosh, Kerrie, Author
Balakrishnan, Karuppiah, Author
Ghei, Satish, Author
Fisher, Simon E.1, Author           
Golding, Marina, Author
Narayan, Nallakandy P. Shanker, Author
Sitaraman, Thiagarajan, Author
Sengupta, Utpal, Author
Pitchappan, Ramasamy, Author
Hill, Adrian V.S., Author
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1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., ou_persistent22              

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 Abstract: Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS) = 4.09, P < 2x10-5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs.

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 Dates: 2001
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/86958
PMID: 11279529
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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 27 Sequence Number: - Start / End Page: 439 - 441 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609