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  A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium

Bailey, A., Hervas, A., Matthews, N., Palferman, S., Wallace, S., Aubin, A., et al. (1998). A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. Human Molecular Genetics, 7(3), 571-578. doi:10.1093/hmg/7.3.571.

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Bailey_et_al_A_Full_Genome_Screen_Human_Molecular)Gen_1998.pdf (Verlagsversion), 621KB
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Bailey_et_al_A_Full_Genome_Screen_Human_Molecular)Gen_1998.pdf
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 Urheber:
Bailey, Anthony1, Autor
Hervas, Amaia, Autor
Matthews, Nicola, Autor
Palferman, Sarah, Autor
Wallace, Simon, Autor
Aubin, Anne, Autor
Michelotti, Janine, Autor
Wainhouse, Catherine, Autor
Papanikolaou, Katerina, Autor
Rutter, Michael, Autor
Maestrini, Elena, Autor
Marlow, Angela, Autor
Weeks, Daniel E., Autor
Lamb, Janine, Autor
Francks, Clyde1, Autor           
Kearsley, Georgina, Autor
Scudder, Pat, Autor
Monaco, Anthony P., Autor
Baird, Gillian, Autor
Cox, Anthony, Autor
Cockerill, Helen, AutorNuffield, Fleming, AutorLe Couteur, Ann, AutorBerney, Tom, AutorCooper, Hayley, AutorKelly, Tom, AutorGreen, Jonathan, AutorWhittaker, Jane, AutorGilchrist, Anne, AutorBolton, Patrick, AutorSchönewald, Anne, AutorDaker, Michael, AutorOgilvie, Caroline, AutorDocherty, Zoe, AutorDeans, Zandra, AutorBolton, Bryan, AutorPacker, Ros, AutorPoustka, Fritz, AutorRühl, Dorothea, AutorSchmötzer, Gabriele, AutorBölte, Sven, AutorKlauck, Sabine M, AutorSpieler, Anja, AutorPoustka., Annemarie, AutorVan Engeland, Herman , AutorKemner, Chantal, AutorDe Jonge, Maretha , AutorDen Hartog, Ineke, AutorLord, Catherine, AutorCook, Edwin, AutorLeventhal, Bennett, AutorVolkmar, Fred, AutorPauls, David, AutorKlin, Ami, AutorSmalley, Susan, AutorFombonne, Eric, AutorRogé, Bernadette, AutorTauber, Maite, AutorArti-Vartayan, Evelyne, AutorFremolle-Kruck., Jeanne, AutorPederson, Lennart, AutorHaracopos, Demetrious, AutorBrondum-Nielsen, Karen, AutorCotterill, Rodney, Autor mehr..
Affiliations:
1 International Molecular Genetic Study of Autism Consortium, ou_persistent22              

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 Zusammenfassung: Autism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search for susceptibility loci in autism was performed on 87 affected sib pairs plus 12 non-sib affected relative-pairs, from a total of 99 families identified by an international consortium. Regions on six chromosomes (4, 7, 10, 16, 19 and 22) were identified which generated a multipoint maximum lod score (MLS) > 1. A region on chromosome 7q was the most significant with an MLS of 3.55 near markers D7S530 and D7S684 in the subset of 56 UK affected sib-pair families, and an MLS of 2.53 in all 87 affected sib-pair families. An area on chromosome 16p near the telomere was the next most significant, with an MLS of 1.97 in the UK families, and 1.51 in all families. These results are an important step towards identifying genes predisposing to autism; establishing their general applicability requires further study.

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 Datum: 1998
 Publikationsstatus: Erschienen
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1093/hmg/7.3.571
 Art des Abschluß: -

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Titel: Human Molecular Genetics
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford, England : IRL Press
Seiten: - Band / Heft: 7 (3) Artikelnummer: - Start- / Endseite: 571 - 578 Identifikator: Anderer: 954925581153
ISSN: 0964-6906
CoNE: https://pure.mpg.de/cone/journals/resource/954925581153