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  LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia

Francks, C., Maegawa, S., Laurén, J., Abrahams, B. S., Velayos-Baeza, A., Medland, S. E., et al. (2007). LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Molecular Psychiatry, 12, 1129-1139. doi:10.1038/sj.mp.4002053.

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Francks_LRRTM1_on_chromosome2p12_Mol_psych_2007.pdf (Verlagsversion), 432KB
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Francks_LRRTM1_on_chromosome2p12_Mol_psych_2007.pdf
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Francks, Clyde1, Autor           
Maegawa, S., Autor
Laurén, J., Autor
Abrahams, B. S., Autor
Velayos-Baeza, A., Autor
Medland, S. E., Autor
Colella, S., Autor
Groszer, M., Autor
McAuley, E. Z., Autor
Caffrey, T. M., Autor
Timmusk, T., Autor
Pruunsild, P., Autor
Koppel, I., Autor
Lind, P. A., Autor
Matsumoto-Itaba, N., Autor
Nicod, J., Autor
Xiong, L., Autor
Joober, R., Autor
Enard, W., Autor
Krinsky, B., Autor
Nanba, E., AutorRichardson, A. J., AutorRiley, B. P., AutorMartin, N. G., AutorStrittmatter, S. M., AutorMöller, H-J , AutorRujescu, D., AutorSt Clair, D., AutorMuglia, P., AutorRoos, J. L., AutorFisher, Simon E.1, Autor           Wade-Martins, R., AutorRouleau, G. A., AutorStein, J. F., AutorKarayiorgou, M., AutorGeschwind, D. H., AutorRagoussis, J., AutorKendler, K. S., AutorAiraksinen, M. S., AutorOshimura, M., AutorDeLisi, L. E., AutorMonaco, A. P., Autor mehr..
Affiliations:
1Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, ou_persistent22              

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 Zusammenfassung: Left-right asymmetrical brain function underlies much of human cognition, behavior and emotion. Abnormalities of cerebral asymmetry are associated with schizophrenia and other neuropsychiatric disorders. The molecular, developmental and evolutionary origins of human brain asymmetry are unknown. We found significant association of a haplotype upstream of the gene LRRTM1 (Leucine-rich repeat transmembrane neuronal 1) with a quantitative measure of human handedness in a set of dyslexic siblings, when the haplotype was inherited paternally (P=0.00002). While we were unable to find this effect in an epidemiological set of twin-based sibships, we did find that the same haplotype is overtransmitted paternally to individuals with schizophrenia/schizoaffective disorder in a study of 1002 affected families (P=0.0014). We then found direct confirmatory evidence that LRRTM1 is an imprinted gene in humans that shows a variable pattern of maternal downregulation. We also showed that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity. This is the first potential genetic influence on human handedness to be identified, and the first putative genetic effect on variability in human brain asymmetry. LRRTM1 is a candidate gene for involvement in several common neurodevelopmental disorders, and may have played a role in human cognitive and behavioral evolution.

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Sprache(n): eng - English
 Datum: 2007
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/sj.mp.4002053
PMID: 17667961
 Art des Abschluß: -

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Titel: Molecular Psychiatry
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Houndmills, Hampshire, UK : Stockton Press
Seiten: - Band / Heft: 12 Artikelnummer: - Start- / Endseite: 1129 - 1139 Identifikator: Anderer: 954925619131
ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131