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  Fucose Migration in Intact Protonated Glycan Ions: A Universal Phenomenon in Mass Spectrometry

Mucha, E., Lettow, M., Marianski, M., Thomas, D., Struwe, W. B., Harvey, D. J., et al. (2018). Fucose Migration in Intact Protonated Glycan Ions: A Universal Phenomenon in Mass Spectrometry. Angewandte Chemie International Edition, 57. doi:10.1002/anie.201801418.

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 Creators:
Mucha, Eike1, 2, Author           
Lettow, Maike1, 2, Author
Marianski, Mateusz1, Author           
Thomas, Daniel1, Author           
Struwe, Weston B.3, Author
Harvey, David J.4, Author
Meijer, Gerard1, Author           
Seeberger, Peter H.5, 6, Author           
Helden, Gert von1, Author           
Pagel, Kevin1, 2, Author           
Affiliations:
1Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              
2Institut für Chemie und Biochemie der Freien Universität Berlin, Takustraße 3, 14195 Berlin,Germany, ou_persistent22              
3Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK, ou_persistent22              
4Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK, ou_persistent22              
5Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              
6Institut für Chemie und Biochemie der Freien Universität Berlin, Arnimallee 22, 14195 Berlin,Germany, ou_persistent22              

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Free keywords: carbohydrates fucose glycans IR spectroscopy mass spectrometry
 Abstract: Fucose is an essential deoxysugar that is found in a wide range of biologically relevant glycans and glycoconjugates. A recurring problem in mass spectrometric analyses of fucosylated glycans is the intramolecular migration of fucose units, which can lead to erroneous sequence assignments. This migration reaction is typically assigned to activation during collision‐induced dissociation (CID) in tandem mass spectrometry (MS). In this work, we utilized cold‐ion spectroscopy and show for the first time that fucose migration is not limited to fragments obtained in tandem MS and can also be observed in intact glycan ions. This observation suggests a possible low‐energy barrier for this transfer reaction and generalizes fucose migration to an issue that may universally occur in any type of mass spectrometry experiment.

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Language(s): eng - English
 Dates: 2018-02-022018-04-242018-05-25
 Publication Status: Published online
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201801418
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 57 Sequence Number: - Start / End Page: - Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851