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  Biomedical Knowledge Base Construction from Text and its Applications in Knowledge-based Systems

Ernst, P. (2018). Biomedical Knowledge Base Construction from Text and its Applications in Knowledge-based Systems. PhD Thesis, Universität des Saarlandes, Saarbrücken. doi:10.22028/D291-27105.

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Genre: Hochschulschrift

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 Urheber:
Ernst, Patrick1, 2, Autor           
Weikum, Gerhard1, Ratgeber           
Verspoor, Karin3, Gutachter
Berberich, Klaus1, Gutachter           
Affiliations:
1Databases and Information Systems, MPI for Informatics, Max Planck Society, ou_24018              
2International Max Planck Research School, MPI for Informatics, Max Planck Society, ou_1116551              
3External Organizations, ou_persistent22              

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 Zusammenfassung: While general-purpose Knowledge Bases (KBs) have gone a long way in compiling comprehensive knowledgee about people, events, places, etc., domain-specific KBs, such as on health, are equally important, but are less explored. Consequently, a comprehensive and expressive health KB that spans all aspects of biomedical knowledge is still missing. The main goal of this thesis is to develop principled methods for building such a KB and enabling knowledge-centric applications. We address several challenges and make the following contributions: - To construct a health KB, we devise a largely automated and scalable pattern-based knowledge extraction method covering a spectrum of different text genres and distilling a wide variety of facts from different biomedical areas. - To consider higher-arity relations, crucial for proper knowledge representation in advanced domain such as health, we generalize the fact-pattern duality paradigm of previous methods. A key novelty is the integration of facts with missing arguments by extending our framework to partial patterns and facts by reasoning over the composability of partial facts. - To demonstrate the benefits of a health KB, we devise systems for entity-aware search and analytics and for entity-relationship-oriented exploration. Extensive experiments and use-case studies demonstrate the viability of the proposed approaches.

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Sprache(n): eng - English
 Datum: 20172018-03-062018-02-20
 Publikationsstatus: Online veröffentlicht
 Seiten: 147 p.
 Ort, Verlag, Ausgabe: Saarbrücken : Universität des Saarlandes
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: BibTex Citekey: Ernstphd2017
URN: urn:nbn:de:bsz:291-scidok-ds-271051
DOI: 10.22028/D291-27105
 Art des Abschluß: Doktorarbeit

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