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  Automated glycan assembly using the Glyconeer 2.1 synthesizer

Hahm, H. S., Schlegel, M. K., Hurevich, M., Eller, S., Schuhmacher, F., Hofmann, J., et al. (2017). Automated glycan assembly using the Glyconeer 2.1 synthesizer. Proceedings of the National Academy of Sciences of the United States of America, 114(17), E3385-E3389. doi:10.1073/pnas.1700141114.

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Hahm, Heung Sik1, 2, Autor           
Schlegel, Mark K.1, 3, Autor           
Hurevich, Mattan4, Autor           
Eller, Steffen4, Autor           
Schuhmacher, Frank1, 2, Autor           
Hofmann, Johanna2, 5, Autor           
Pagel, Kevin2, 5, Autor           
Seeberger, Peter H.1, 2, Autor           
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
2Institute of Chemistry and Biochemistry, Free University Berlin, 14195 Berlin, Germany, ou_persistent22              
3GlycoUniverse GmbH & Co. KGaA, 14195 Berlin, Germany, ou_persistent22              
4Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              
5Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              

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Schlagwörter: oligosaccharide synthesis; automated synthesis; glycochemistry; glycobiology; Glyconeer
 Zusammenfassung: Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure–activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosaccharides using the commercially available Glyconeer 2.1 automated glycan synthesizer, monosaccharide building blocks, and a linker-functionalized polystyrene solid support. Purification and quality-control protocols for the oligosaccharide products have been standardized. Synthetic glycans prepared in this way are useful reagents as the basis for glycan arrays, diagnostics, and carbohydrate-based vaccines.

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Sprache(n): eng - English
 Datum: 2017-04-102017-04-25
 Publikationsstatus: Erschienen
 Seiten: 5
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1073/pnas.1700141114
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : Proc. Acad. Sci. USA
  Andere : Proc. Acad. Sci. U.S.A.
  Kurztitel : PNAS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 114 (17) Artikelnummer: - Start- / Endseite: E3385 - E3389 Identifikator: ISSN: 0027-8424