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  Selecting Optimal Minimum Spanning Trees that Share a Topological Correspondence with Phylogenetic Trees

Kalaghatgi, P., & Lengauer, T. (2017). Selecting Optimal Minimum Spanning Trees that Share a Topological Correspondence with Phylogenetic Trees. Retrieved from http://arxiv.org/abs/1701.02844.

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arXiv:1701.02844.pdf (Preprint), 455KB
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 Creators:
Kalaghatgi, Prabhav1, Author           
Lengauer, Thomas1, Author           
Affiliations:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046              

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Free keywords: Mathematics, Combinatorics, math.CO,Computer Science, Data Structures and Algorithms, cs.DS
 Abstract: Choi et. al (2011) introduced a minimum spanning tree (MST)-based method called CLGrouping, for constructing tree-structured probabilistic graphical models, a statistical framework that is commonly used for inferring phylogenetic trees. While CLGrouping works correctly if there is a unique MST, we observe an indeterminacy in the method in the case that there are multiple MSTs. In this work we remove this indeterminacy by introducing so-called vertex-ranked MSTs. We note that the effectiveness of CLGrouping is inversely related to the number of leaves in the MST. This motivates the problem of finding a vertex-ranked MST with the minimum number of leaves (MLVRMST). We provide a polynomial time algorithm for the MLVRMST problem, and prove its correctness for graphs whose edges are weighted with tree-additive distances.

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Language(s): eng - English
 Dates: 2017-01-102017
 Publication Status: Published online
 Pages: 16 pages, 5 figures
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: arXiv: 1701.02844
URI: http://arxiv.org/abs/1701.02844
BibTex Citekey: Kalaghatgi2017
 Degree: -

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