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  Selective modulation of cell response on engineered fractal silicon substrates

Gentile, F., Medda, R., Cheng, L., Battista, E., Scopelliti, P. E., Milani, P., et al. (2013). Selective modulation of cell response on engineered fractal silicon substrates. Scientific Reports, 3: 1461, pp. 1-10. doi:10.1038/srep01461.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-764B-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-C867-8
Genre: Journal Article

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 Creators:
Gentile, Francesco, Author
Medda, Rebecca1, Author              
Cheng, Ling, Author
Battista, Edmondo, Author
Scopelliti, Pasquale E., Author
Milani, Paolo, Author
Cavalcanti-Adam, Elisabetta Ada1, Author              
Decuzzi, Paolo, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, escidoc:2364731              

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Free keywords: Cell growth; Focal adhesion; Nanoscale biophysics; Tissue engineering and regenerative medicine
 Abstract: A plethora of work has been dedicated to the analysis of cell behavior on substrates with ordered topographical features. However, the natural cell microenvironment is characterized by biomechanical cues organized over multiple scales. Here, randomly rough, self-affinefractal surfaces are generated out of silicon,where roughness Ra and fractal dimension Df are independently controlled. The proliferation rates, the formation of adhesion structures, and the morphology of 3T3 murine fibroblasts are monitored over six different substrates. The proliferation rate is maximized on surfaces with moderate roughness (Ra ~ 40 nm) and large fractal dimension (Df ~ 2.4); whereas adhesion structures are wider and more stable on substrates with higher roughness (Ra ~ 50 nm) and lower fractal dimension (Df ~ 2.2). Higher proliferation occurson substrates exhibiting densely packed and sharp peaks, whereas more regular ridges favor adhesion. These results suggest that randomly roughtopographies can selectively modulate cell behavior.

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Language(s): eng - English
 Dates: 2012-12-122013-02-262013-03-15
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/srep01461
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 3 Sequence Number: 1461 Start / End Page: 1 - 10 Identifier: ISSN: 2045-2322
CoNE: http://pubman.mpdl.mpg.de/cone/journals/resource/2045-2322