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  Expression of blood serum proteins and lymphocyte differentiation clusters after chronic occupational exposure to ionizing radiation

Rybkina, V. L., Azizova, T. V., Scherthan, H., Meineke, V., Doerr, H., Adamova, G. V., et al. (2014). Expression of blood serum proteins and lymphocyte differentiation clusters after chronic occupational exposure to ionizing radiation. Radiation and Environmental Biophysics, 53(4), 659-670. doi:10.1007/s00411-014-0556-3.

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Rybkina.pdf (Verlagsversion), 357KB
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© 2014 Springer International Publishing AG, Part of Springer Science+Business Media
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http://www.ncbi.nlm.nih.gov/pubmed/25073961 (beliebiger Volltext)
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 Urheber:
Rybkina, V. L., Autor
Azizova, T. V., Autor
Scherthan, H.1, 2, Autor           
Meineke, V., Autor
Doerr, H., Autor
Adamova, G. V., Autor
Teplyakova, O. V., Autor
Osovets, S. V., Autor
Bannikova, M. V., Autor
Zurochka, A. V., Autor
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Bundeswehr Institute of Radiobiology, University of Ulm, Munich, Germany , ou_persistent22              

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 Zusammenfassung: This study aimed to assess effects of chronic occupational exposure on immune status in Mayak workers chronically exposed to ionizing radiation (IR). The study cohort consists of 77 workers occupationally exposed to external gamma-rays at total dose from 0.5 to 3.0 Gy (14 individuals) and workers with combined exposure (external gamma-rays at total dose range 0.7-5.1 Gy and internal alpha-radiation from incorporated plutonium with a body burden of 0.3-16.4 kBq). The control group consists of 43 age- and sex-matched individuals who never were exposed to IR, never involved in any cleanup operations following radiation accidents and never resided at contaminated areas. Enzyme-linked immunoassay and flow cytometry were used to determine the relative concentration of lymphocytes and proteins. The concentrations of T-lymphocytes, interleukin-8 and immunoglobulins G were decreased in external gamma-exposed workers relative to control. Relative concentrations of NKT-lymphocytes, concentrations of transforming growth factor-beta, interferon gamma, immunoglobulins A, immunoglobulins M and matrix proteinase-9 were higher in this group as compared with control. Relative concentrations of T-lymphocytes and concentration of interleukin-8 were decreased, while both the relative and absolute concentration of natural killers, concentration of immunoglobulins A and M and matrix proteinase-9 were increased in workers with combined exposure as compared to control. An inverse linear relation was revealed between absolute concentration of T-lymphocytes, relative and absolute concentration of T-helpers cells, concentration of interferon gamma and total absorbed dose from external gamma-rays in exposed workers. For workers with incorporated plutonium, there was an inverse linear relation of absolute concentration of T-helpers as well as direct linear relation of relative concentration of NKT-lymphocytes to total absorbed red bone marrow dose from internal alpha-radiation. In all, chronic occupational IR exposure of workers induced a depletion of immune cells in peripheral blood of the individuals involved.

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Sprache(n): eng - English
 Datum: 2014-07-302014-11
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1007/s00411-014-0556-3
ISSN: 1432-2099 (Electronic)0301-634X (Print)
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Titel: Radiation and Environmental Biophysics
  Andere : Radiat. Environ. Biophys.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Berlin : Springer-Verlag
Seiten: - Band / Heft: 53 (4) Artikelnummer: - Start- / Endseite: 659 - 670 Identifikator: ISSN: 0301-634X
CoNE: https://pure.mpg.de/cone/journals/resource/954925510402