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  Epigenetic remodelling and dysregulation of DLGAP4 is linked with early-onset cerebellar ataxia

Minocherhomji, S., Hansen, C., Kim, H.-G., Mang, Y., Bak, M., Guldberg, P., et al. (2014). Epigenetic remodelling and dysregulation of DLGAP4 is linked with early-onset cerebellar ataxia. Human Molecular Genetics, 23(23), 6163-6176. doi:10.1093/hmg/ddu337.

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http://www.ncbi.nlm.nih.gov/pubmed/24986922 (beliebiger Volltext)
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 Urheber:
Minocherhomji, S., Autor
Hansen, C., Autor
Kim, H.-G.1, Autor           
Mang, Y., Autor
Bak, M., Autor
Guldberg, P., Autor
Papadopoulos, N., Autor
Eiberg, H., Autor
Doh, G. D., Autor
Møllgard, K., Autor
Hertz, J. M., Autor
Nielsen, J. E., Autor
Ropers, H.-H.1, Autor           
Tumer, Z., Autor
Tommerup, N., Autor
Kalscheuer, V. M.2, Autor           
Silahtaroglu, A., Autor
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Chromosome Rearrangements and Disease (Vera Kalscheuer), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479642              

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 Zusammenfassung: Genome instability, epigenetic remodelling and structural chromosomal rearrangements are hallmarks of cancer. However, the coordinated epigenetic effects of constitutional chromosomal rearrangements that disrupt genes associated with congenital neurodevelopmental diseases are poorly understood. To understand the genetic-epigenetic interplay at breakpoints of chromosomal translocations disrupting CG-rich loci, we quantified epigenetic modifications at DLGAP4 (SAPAP4), a key post-synaptic density 95 (PSD95) associated gene, truncated by the chromosome translocation t(8;20)(p12;q11.23), co-segregating with cerebellar ataxia in a five-generation family. We report significant epigenetic remodelling of the DLGAP4 locus triggered by the t(8;20)(p12;q11.23) translocation and leading to dysregulation of DLGAP4 expression in affected carriers. Disruption of DLGAP4 results in monoallelic hypermethylation of the truncated DLGAP4 promoter CpG island. This induced hypermethylation is maintained in somatic cells of carriers across several generations in a t(8;20) dependent-manner however, is erased in the germ cells of the translocation carriers. Subsequently, chromatin remodelling of the locus-perturbed monoallelic expression of DLGAP4 mRNAs and non-coding RNAs in haploid cells having the translocation. Our results provide new mechanistic insight into the way a balanced chromosomal rearrangement associated with a neurodevelopmental disorder perturbs allele-specific epigenetic mechanisms at breakpoints leading to the deregulation of the truncated locus.

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Sprache(n): eng - English
 Datum: 2014-07-012014-12-01
 Publikationsstatus: Erschienen
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1093/hmg/ddu337
ISSN: 1460-2083 (Electronic)0964-6906 (Print)
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Titel: Human Molecular Genetics
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford, England : IRL Press
Seiten: - Band / Heft: 23 (23) Artikelnummer: - Start- / Endseite: 6163 - 6176 Identifikator: ISSN: 0964-6906
CoNE: https://pure.mpg.de/cone/journals/resource/954925581153