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  Ring-Closing Alkyne Metathesis Approach toward the Synthesis of Alkyne Mimics of Thioether A-, B-, C-, and DE-Ring Systems of the Lantibiotic Nisin Z

Ghalit, N., Poot, A. J., Fürstner, A., Rijkers, D. T. S., & Liskamp, R. M. J. (2005). Ring-Closing Alkyne Metathesis Approach toward the Synthesis of Alkyne Mimics of Thioether A-, B-, C-, and DE-Ring Systems of the Lantibiotic Nisin Z. Organic Letters, 7(14), 2961-2964. doi:10.1021/ol0508781.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0025-AA6C-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0025-AA6D-8
Genre: Journal Article

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 Creators:
Ghalit, Nourdin1, Author
Poot, Alex J.1, Author
Fürstner, Alois2, Author           
Rijkers, Dirk T. S.1, Author
Liskamp, Rob M. J.1, Author
Affiliations:
1Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands, ou_persistent22              
2Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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 Abstract: Ring-closing alkyne metathesis toward the synthesis of the alkyne-brigded A-, B-, C-, and (D)E-ring mimics of the peptide antibiotic nisin Z is described. We have successfully synthesized alkyne-bridged cyclic peptides containing 4−7 amino acid residues in yields ranging from 18 to 82%.

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Language(s): eng - English
 Dates: 2005-04-212005-06-042005-07-07
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ol0508781
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Title: Organic Letters
  Other : Org. Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 7 (14) Sequence Number: - Start / End Page: 2961 - 2964 Identifier: ISSN: 1523-7060
CoNE: https://pure.mpg.de/cone/journals/resource/954925626338