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  Concise Total Synthesis of Cruentaren A

Fürstner, A., Bindl, M., & Jean, L. (2007). Concise Total Synthesis of Cruentaren A. Angewandte Chemie International Edition, 46(48), 9275-9278. doi:10.1002/anie.200703839.

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 Creators:
Fürstner, A.1, Author           
Bindl, M.1, Author           
Jean, L.1, Author           
Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: alkynes; macrolides; metathesis; natural products; protecting groups
 Abstract: Converging on the target: The highly cytotoxic F-ATPase inhibitor cruentaren A constitutes an interesting lead in the quest for innovative chemotherapeutic agents for the treatment of various diseases, including cancer. Its synthesis was achieved in an overall yield of 3 % by an expeditious convergent route involving a ring-closing alkyne metathesis reaction (RCAM) for the formation of the macrocyclic ring.

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Language(s): eng - English
 Dates: 2007-08-212007-10-312007-12-10
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200703839
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA
Pages: - Volume / Issue: 46 (48) Sequence Number: - Start / End Page: 9275 - 9278 Identifier: ISSN: 1521-3773
CoNE: https://pure.mpg.de/cone/journals/resource/0570-0833