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  Presynaptic inhibition of elicited neurotransmitter release

Wu, L.-G., & Saggau, P. (1997). Presynaptic inhibition of elicited neurotransmitter release. Trends in Neurosciences, 20(5), 204-212. doi:10.1016/S0166-2236(96)01015-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-CEFF-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-CF00-2
Genre: Journal Article
: Presynaptic inhibition of elicited neurotransmitter release

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TiNS_20_1997_204.pdf (Any fulltext), 656KB
 
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 Creators:
Wu, Ling-Gang1, Author              
Saggau, Peter, Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, escidoc:1497701              

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Free keywords: synaptic transmission; presynaptic inhibition; neurotransmitter release; voltage−dependent calcium channel; neuromodulator; presynaptic receptor; cooperative mechanisms
 Abstract: Activation of presynaptic receptors for a variety of neurotransmitters and neuromodulators inhibits transmitter release at many synapses. Such presynaptic inhibition might serve as a means of adjusting synaptic strength or preventing excessive transmitter release, or both. Previous evidence showed that presynaptic modulators inhibit Ca2+ channels and activate K+ channels at neuronal somata. These modulators also inhibit spontaneous transmitter release by mechanisms downstream of Ca2+ entry. The relative contribution of the above mechanisms to the inhibition of elicited release has been debated for a long time. Recent evidence at synapses where the relationship between transmitter release and presynaptic Ca2+ influx has been well characterized suggests that inhibition of presynaptic voltage-dependent Ca2+ channels plays the major role in presynaptic inhibition of elicited neurotransmitter release. In addition, modulation of the release machinery might contribute to inhibition of elicited release

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Language(s): eng - English
 Dates: 1997-05-01
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Trends in Neurosciences
  Other : Trends Neurosci.
Source Genre: Journal
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Publ. Info: Oxford : Elsevier Current Trends
Pages: - Volume / Issue: 20 (5) Sequence Number: - Start / End Page: 204 - 212 Identifier: ISSN: 0166-2236
CoNE: http://pubman.mpdl.mpg.de/cone/journals/resource/954927741850