English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Glutamate receptor channels, RNA editing and epilepsy

Seeburg, P. H., Brusa, R., Higuchi, M., & Sprengel, R. (1997). Glutamate receptor channels, RNA editing and epilepsy. In Excitatory amino acids: from genes to therapy (Ernst Schering research foundation workshop; 23) (pp. 1-17). Heidelberg: Springer.

Item is

Basic

show hide
Genre: Book Chapter
Alternative Title : Glutamate receptor channels, RNA editing and epilepsy

Files

show Files
hide Files
:
Seeburg_1998_Excitatory Amino Acids_1.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
Seeburg_1998_Excitatory Amino Acids_1.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Seeburg, Peter H.1, Author           
Brusa, Rossella1, Author           
Higuchi, Miyoko1, Author           
Sprengel, Rolf1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: In the mammalian central nervous system (CNS) fast excitatory neurotransmission is mediated by ionotropic glutamate receptors (GluRs) of the AMPA/kainate and NMDA receptor families (Collingridge and Lester 1989; Mayer and Westbrook 1987; Watkins et al. 1990). The AMPA receptors mediate the fast component of excitatory postsynaptic currents, whereas the slow component is contributed by NMDA receptors (e.g., Stern et al. 1992). The latter can be viewed as coincidence detectors of pre- and postsynaptic activity, since the gating of the integral ion channel requires two closely simultaneous events, presynaptic release of glutamate and depolarization of the postsynaptic membrane. Depolarization is induced primarily by the activation of synaptically colocalized AMPA receptors. Coincidence detection by the NMDA receptor rests on its voltage-dependent channel block by extracellular Mg2+. NMDA receptors are designed for high Ca2+ permeability, and Ca2+ influx through the NMDA receptor channel is thought to be essential for activity-dependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca2+ influx through NMDA receptors has pathophysiological consequences, including epileptiform activities and neurodegeneration (Choi 1988). By contrast, Mg2+. NMDA receptors are designed for high Ca2+ permeability, and Ca2+ influx through the NMDA receptor channel is thought to be essential for activitydependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca2+ influx through NMDA receptors has pathophysiological consequences, including epileptiform activities and neurodegeneration (Choi 1988)

Details

show
hide
Language(s): eng - English
 Dates: 1997
 Publication Status: Issued
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Internal
 Identifiers: eDoc: 665955
Other: 5597
DOI: 10.1007/978-3-662-03596-2_1
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Excitatory amino acids : from genes to therapy (Ernst Schering research foundation workshop ; 23)
Source Genre: Book
 Creator(s):
Seeburg, P. H.1, Author           
Bresink, I., Author
Turski, L., Author
Affiliations:
1 Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704            
Publ. Info: Heidelberg : Springer
Pages: - Volume / Issue: 23 Sequence Number: - Start / End Page: 1 - 17 Identifier: ISBN: 978-3-662-03598-6
ISBN: 978-3-662-03596-2