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  Coincidence detection and changes of synaptic efficacy in spiny stellate neurons in rat barrel cortex

Egger, V., Feldmeyer, D., & Sakmann, B. (1999). Coincidence detection and changes of synaptic efficacy in spiny stellate neurons in rat barrel cortex. Nature Neuroscience, 2(12), 1098-1105. doi:10.1038/16026.

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Genre: Journal Article
Alternative Title : Coincidence detection and changes of synaptic efficacy in spiny stellate neurons in rat barrel cortex

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NatNeurosci_2_1999_1098.pdf (Any fulltext), 308KB
 
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Egger, Veronica1, Author           
Feldmeyer, Dirk1, Author           
Sakmann, Bert1, Author           
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Paired whole-cell voltage recordings were made from synaptically connected spiny stellate neurons in layer 4 of the barrel field in young (P14) rat somatosensory cortex. When postsynaptic action potentials (APs) followed each of 5 presynaptic APs in a 10- or 20-Hz train by less than 25 ms, subsequent unitary EPSP amplitudes were persistently reduced. Induction of long-term depression (LTD) depended on activation of group II metabotropic glutamate receptors, but not on NMDA or AMPA receptors. Reducing postsynaptic increases in intracellular calcium ([Ca2+]i) by intracellular loading with a fast- (BAPTA) or a slow- (EGTA) acting Ca2+ buffer blocked synaptic depression. Analysis of EPSP failures suggested mediation of LTD by a reduction in release probability. We propose a mechanism by which coincident activity results in long-lasting reduction of synaptic efficacy between synaptically connected neurons

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Language(s): eng - English
 Dates: 1999-09-031999-10-121999-12-01
 Publication Status: Issued
 Pages: 8
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 Rev. Type: Peer
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 2 (12) Sequence Number: - Start / End Page: 1098 - 1105 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931