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  Bispidine Analogues of Cisplatin, Carboplatin, and Oxaliplatin. Synthesis, Structures, and Cytotoxicity

Cui, H., Goddard, R., Pörschke, K.-R., Hamacher, A., & Kassack, M. (2014). Bispidine Analogues of Cisplatin, Carboplatin, and Oxaliplatin. Synthesis, Structures, and Cytotoxicity. Inorganic Chemistry, 53(7), 3371-3384. doi:10.1021/ic402737f.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-9B23-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-9B24-D
Genre: Journal Article

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 Creators:
Cui, Huiling1, Author           
Goddard, Richard2, Author           
Pörschke, Klaus-Richard1, Author           
Hamacher, Alexandra3, Author
Kassack, Matthias3, Author
Affiliations:
1Research Group Pörschke, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445616              
2Service Department Lehmann (EMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445625              
3Institut für Pharmazeutische und Medizinische Chemie der Heinrich-Heine-Universität Düsseldorf, ou_persistent22              

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Free keywords: NUCLEAR-MAGNETIC-RESONANCE; MIT UROTROPIN-STRUKTUR; CRYSTAL-STRUCTURE; PLATINUM(II) COMPLEXES; X-RAY; MOLECULAR-STRUCTURE; CLINICAL-EXPERIENCE; DICHLOROPLATINUM(II) COMPLEX; DES 1.3-DIAZA-ADAMANTANS; PALLADIUM(II) COMPLEXES
 Abstract: Bispidine analogues 1−3 of cisplatin, carboplatin, and oxaliplatin have been prepared, including some DMF and water solute complexes. The crystal structures reveal various patterns of N−H···Cl and N−H···O hydrogen bonds. For the hydrates of 1 and 2, different modes of water solvation were found. The compounds have been tested for their cytotoxicity against standard human cancer cell lines, revealing significant cytotoxic activity along with a low platinum resistance factor R.

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Language(s): eng - English
 Dates: 2014-03-252014-04-07
 Publication Status: Issued
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ic402737f
 Degree: -

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Title: Inorganic Chemistry
  Abbreviation : Inorg. Chem.
Source Genre: Journal
 Creator(s):
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Publ. Info: Washington, USA : American Chemical Society
Pages: - Volume / Issue: 53 (7) Sequence Number: - Start / End Page: 3371 - 3384 Identifier: ISSN: 0020-1669
CoNE: https://pure.mpg.de/cone/journals/resource/0020-1669