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  Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning

Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., et al. (1999). Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science, 284, 1805-1811. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10364547.

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Genre: Zeitschriftenartikel
Alternativer Titel : Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning

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Science_284_1999_1805.pdf (beliebiger Volltext), 670KB
 
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http://www.sciencemag.org/content/284/5421/1805.full.pdf (beliebiger Volltext)
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http://dx.doi.org/10.1126/science.284.5421.1805 (beliebiger Volltext)
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 Urheber:
Zamanillo, Daniel1, Autor           
Sprengel, Rolf1, Autor           
Hvalby, Øivind, Autor
Jensen, Vidar, Autor
Burnashev, Nail2, Autor           
Rozov, Andrej1, 2, Autor           
Kaiser, Katharina2, Autor           
Köster, Helmut Joachim2, Autor           
Borchardt, Thilo1, Autor           
Worley, Paul F., Autor
Lübke, Joachim H. R., Autor
Frotscher, Michael, Autor
Kelly, Peter H., Autor
Sommer, Bernd, Autor
Andersen, Per, Autor
Seeburg, Peter H.1, Autor           
Sakmann, Bert2, Autor           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Zusammenfassung: Gene-targeted mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses. In hippocampal CA1 pyramidal neurons, GluR-A-/- mice showed a reduction in functional AMPA receptors, with the remaining receptors preferentially targeted to synapses. Thus, the CA1 soma-patch currents were strongly reduced, but glutamatergic synaptic currents were unaltered; and evoked dendritic and spinous Ca2+ transients, Ca2+-dependent gene activation, and hippocampal field potentials were as in the wild type. In adult GluR-A-/- mice, associative long-term potentiation (LTP) was absent in CA3 to CA1 synapses, but spatial learning in the water maze was not impaired. The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory

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Sprache(n): eng - English
 Datum: 1999-03-031999-05-111999-06-11
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
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Titel: Science
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, D.C. : American Association for the Advancement of Science
Seiten: - Band / Heft: 284 Artikelnummer: - Start- / Endseite: 1805 - 1811 Identifikator: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1