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  CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity

Roiban, G.-D., Agudo Torres, R., Ilie, A., Londsdale, R., & Reetz, M. T. (2014). CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity. Chemical Communications, 50(92), 14310-14313. doi:10.1039/C4CC04925J.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-5739-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-573A-0
Genre: Journal Article

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 Creators:
Roiban, Georghe-Doru1, 2, Author           
Agudo Torres, Rubén1, 2, Author           
Ilie, Adriana1, 2, Author           
Londsdale, Richard1, 2, Author           
Reetz, Manfred T.1, 2, Author           
Affiliations:
1Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              
2Philipps-Universität Marburg, Fachbereich Chemie, ou_persistent22              

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 Abstract: Mutants of P450-BM3 evolved by directed evolution are excellent catalysts in the CH-activating oxidative hydroxylation of 1-tetralone derivatives and of indanone, with unusually high regio- and enantioselectivity being observed. Similar results were achieved in the oxidative hydroxylation of tetralin and indane. The products are useful building blocks in the synthesis of a number of biologically active compounds.

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Language(s): eng - English
 Dates: 2014-08-22
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/C4CC04925J
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Pages: - Volume / Issue: 50 (92) Sequence Number: - Start / End Page: 14310 - 14313 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413