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  High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains

Moreth, K., Fischer, R., Fuchs, H., Gailus-Durner, V., Wurst, W., Wurst, W., et al. (2014). High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 184(6), 763-775. doi:10.1007/s00360-014-0830-3.

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Moreth, Kristin1, Author
Fischer, Ralf1, Author
Fuchs, Helmut1, Author
Gailus-Durner, Valerie1, Author
Wurst, Wolfgang1, Author
Wurst, Wolfgang2, 3, Author           
Katus, Hugo A.1, Author
Bekeredjian, Raffi1, Author
de Angelis, Martin Hrabe1, Author
Affiliations:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, ou_persistent22              

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 Abstract: Mice with genetic alterations are used in heart research as model systems of human diseases. In the last decade there was a marked increase in the recognition of genetic diversity within inbred mouse strains. Increasing numbers of inbred mouse strains and substrains and analytical variation of cardiac phenotyping methods require reproducible, high-throughput methods to standardize murine cardiovascular physiology. We describe methods for non-invasive, reliable, easy and fast to perform echocardiography and electrocardiography on awake mice. This method can be used for primary screening of the murine cardiovascular system in large-scale analysis. We provide insights into the physiological divergence of C57BL/6N, C57BL/6J, C3HeB/FeJ and 129P2/OlaHsd mouse hearts and define the expected normal values. Our report highlights that compared to the other three strains tested C57BL/6N hearts reveal features of heart failure such as hypertrophy and reduced contractile function. We found several features of the mouse ECG to be under genetic control and obtained several strain-specific differences in cardiac structure and function.

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Language(s): eng - English
 Dates: 2014-05-012014-08
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000339886800008
DOI: 10.1007/s00360-014-0830-3
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Title: JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
Source Genre: Journal
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Publ. Info: Berlin, Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 184 (6) Sequence Number: - Start / End Page: 763 - 775 Identifier: ISSN: 0174-1578