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  High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains

Moreth, K., Fischer, R., Fuchs, H., Gailus-Durner, V., Wurst, W., Wurst, W., et al. (2014). High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 184(6), 763-775. doi:10.1007/s00360-014-0830-3.

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Moreth, Kristin1, Autor
Fischer, Ralf1, Autor
Fuchs, Helmut1, Autor
Gailus-Durner, Valerie1, Autor
Wurst, Wolfgang1, Autor
Wurst, Wolfgang2, 3, Autor           
Katus, Hugo A.1, Autor
Bekeredjian, Raffi1, Autor
de Angelis, Martin Hrabe1, Autor
Affiliations:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, ou_persistent22              

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 Zusammenfassung: Mice with genetic alterations are used in heart research as model systems of human diseases. In the last decade there was a marked increase in the recognition of genetic diversity within inbred mouse strains. Increasing numbers of inbred mouse strains and substrains and analytical variation of cardiac phenotyping methods require reproducible, high-throughput methods to standardize murine cardiovascular physiology. We describe methods for non-invasive, reliable, easy and fast to perform echocardiography and electrocardiography on awake mice. This method can be used for primary screening of the murine cardiovascular system in large-scale analysis. We provide insights into the physiological divergence of C57BL/6N, C57BL/6J, C3HeB/FeJ and 129P2/OlaHsd mouse hearts and define the expected normal values. Our report highlights that compared to the other three strains tested C57BL/6N hearts reveal features of heart failure such as hypertrophy and reduced contractile function. We found several features of the mouse ECG to be under genetic control and obtained several strain-specific differences in cardiac structure and function.

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Sprache(n): eng - English
 Datum: 2014-05-012014-08
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000339886800008
DOI: 10.1007/s00360-014-0830-3
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Titel: JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Berlin, Heidelberg : Springer-Verlag
Seiten: - Band / Heft: 184 (6) Artikelnummer: - Start- / Endseite: 763 - 775 Identifikator: ISSN: 0174-1578