English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51

Balsevich, G., Uribe, A., Wagner, K. V., Hartmann, J., Santarelli, S., Labermaier, C., et al. (2014). Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51. JOURNAL OF ENDOCRINOLOGY, 222(1), 15-26. doi:10.1530/JOE-14-0129.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Balsevich, Georgia1, Author           
Uribe, Andres1, Author           
Wagner, Klaus V.2, Author           
Hartmann, Jakob1, Author           
Santarelli, Sara1, Author           
Labermaier, Christiana2, Author           
Schmidt, Mathias V.1, Author           
Affiliations:
1Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Content

show
hide
Free keywords: -
 Abstract: While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface remain elusive. The FK506-binding protein 51 (FKBP51, gene: Fkbp5) has been identified as a target gene implicated in the development of stress-related psychiatric disorders and is a possible candidate for involvement in stress and metabolic regulation. The aims of the current study are to investigate the interaction between chronic stress and an obesogenic context and to additionally examine whether FKBP51 is involved in this interaction. For this purpose, male C57BL/6 mice were exposed to a high-fat diet for 8 weeks before being challenged with chronic social defeat stress. Herein, we demonstrate that chronic stress induces hypophagia and weight loss, ultimately improving features arising from an obesogenic context, including glucose tolerance and levels of insulin and leptin. We show that Fkbp5 expression is responsive to diet and stress in the hypothalamus and hippocampus respectively. Furthermore, under basal conditions, higher levels of hypothalamic Fkbp5 expression were related to increased body weight gain. Our data indicate that Fkbp5 may represent a novel target in metabolic regulation.

Details

show
hide
Language(s): eng - English
 Dates: 2014-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000339256800005
DOI: 10.1530/JOE-14-0129
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: JOURNAL OF ENDOCRINOLOGY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Bristol, UK : Bioscientifica Ltd.
Pages: - Volume / Issue: 222 (1) Sequence Number: - Start / End Page: 15 - 26 Identifier: ISSN: 0022-0795