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  Evidence supporting the match/mismatch hypothesis of psychiatric disorders

Santarelli, S., Lesuis, S. L., Wang, X.-D., Wagner, K. V., Hartmann, J., Labermaier, C., et al. (2014). Evidence supporting the match/mismatch hypothesis of psychiatric disorders. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24(6), 907-918. doi:10.1016/j.euroneuro.2014.02.002.

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Santarelli, Sara1, Autor           
Lesuis, Sylvie L.2, Autor           
Wang, Xiao-Dong2, Autor           
Wagner, Klaus V.2, Autor           
Hartmann, Jakob1, Autor           
Labermaier, Christiana2, Autor           
Scharf, Sebastian H.2, Autor           
Müller, Marianne B.2, Autor           
Holsboer, Florian3, Autor           
Schmidt, Mathias V.1, Autor           
Affiliations:
1Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3Dept. Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035296              

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 Zusammenfassung: Chronic stress is one of the predominant environmental risk factors for a number of psychiatric disorders, particularly for major depression. Different hypotheses have been formulated to address the interaction between early and adult chronic stress in psychiatric disease vulnerability. The match/mismatch hypothesis of psychiatric disease states that the early life environment shapes coping strategies in a manner that enables individuals to optimally face similar environments later in life. We tested this hypothesis in female Balb/c mice that underwent either stress or enrichment early in life and were in adulthood further subdivided in single or group housed, in order to provide aversive or positive adult environments, respectively. We studied the effects,of the environmental manipulation on anxiety-like, depressive-like and sociability behaviors and gene expression profiles. We show that continuous exposure to adverse environments (matched condition) is not necessarily resulting in an opposite phenotype compared to a continuous supportive environment (matched condition). Rather, animals with mismatched environmental conditions behaved differently from animals with matched environments on anxious, social and depressive like phenotypes. These results further support the match/mismatch hypothesis and illustrate how mild or moderate aversive conditions during development can shape an individual to be optimally adapted to similar conditions later in life. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.

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Sprache(n): eng - English
 Datum: 2014-06
 Publikationsstatus: Erschienen
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 Identifikatoren: ISI: 000336871900009
DOI: 10.1016/j.euroneuro.2014.02.002
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Titel: EUROPEAN NEUROPSYCHOPHARMACOLOGY
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Amsterdam : Elsevier Ltd.
Seiten: - Band / Heft: 24 (6) Artikelnummer: - Start- / Endseite: 907 - 918 Identifikator: ISSN: 0924-977X