English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN

Iozzo, P., Holmes, M., Schmidt, M. V., Cirulli, F., Guzzardi, M. A., Berry, A., et al. (2014). Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN. OBESITY FACTS, 7(2), 130-151. doi:10.1159/000362656.

Item is

Files

show Files
hide Files
:
362656.pdf (Any fulltext), 2MB
Name:
362656.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Iozzo, Patricia1, Author
Holmes, Megan1, Author
Schmidt, Mathias V.2, Author           
Cirulli, Francesca1, Author
Guzzardi, Maria Angela1, Author
Berry, Alessandra1, Author
Balsevich, Georgia1, Author
Balsevich, Georgia2, Author           
Andreassi, Maria Grazia1, Author
Wesselink, Jan-Jaap1, Author
Liistro, Tiziana1, Author
Gomez-Puertas, Paulino1, Author
Eriksson, Johan G.1, Author
Seckl, Jonathan1, Author
Affiliations:
1external, ou_persistent22              
2Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              

Content

show
hide
Free keywords: -
 Abstract: Europe has the highest proportion of elderly people in the world. Cardiovascular disease, type 2 diabetes, sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Among conditions which may contribute to establish early risk factors, this review focuses on maternal obesity, since the epidemic of obesity involves an ever growing number of women of reproductive age and children, calling for appropriate studies to understand the consequences of maternal obesity on the offspring's health and for developing effective measures and policies to improve people's health before their conception and birth. Though the current knowledge suggests that the long-term impact of maternal obesity on the offspring's health may be substantial, the outcomes of maternal obesity over the lifespan have not been quantified, and the molecular changes induced by maternal obesity remain poorly characterized. We hypothesize that maternal insulin resistance and reduced placental glucocorticoid catabolism, leading to oxidative stress, may damage the DNA, either in its structure (telomere shortening) or in its function (via epigenetic changes), resulting in altered gene expression/repair, disease during life, and pathological ageing. This review illustrates the background to the EU-FP7-HEALTH-DORIAN project. (C) 2014 S. Karger GmbH, Freiburg

Details

show
hide
Language(s): eng - English
 Dates: 2014-04-302014-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000335957500007
DOI: 10.1159/000362656
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: OBESITY FACTS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Freiburg : S. Karger
Pages: - Volume / Issue: 7 (2) Sequence Number: - Start / End Page: 130 - 151 Identifier: ISSN: 1662-4025