Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Hippocampal Homer1 Levels Influence Motivational Behavior in an Operant Conditioning Task

Wagner, K. V., Häusl, A. S., Pöhlmann, M. L., Hartmann, J., Labermaier, C., Müller, M. B., et al. (2014). Hippocampal Homer1 Levels Influence Motivational Behavior in an Operant Conditioning Task. PLOS ONE, 9(1): e85975. doi:10.1371/journal.pone.0085975.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
journal.pone.0085975.pdf (beliebiger Volltext), 572KB
Name:
journal.pone.0085975.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Wagner, Klaus V.1, Autor           
Häusl, Alexander S.2, Autor           
Pöhlmann, Max L.3, Autor           
Hartmann, Jakob1, Autor           
Labermaier, Christiana2, Autor           
Müller, Marianne B.2, Autor           
Schmidt, Mathias V.3, Autor           
Affiliations:
1AG Schmidt, Mathias, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607156              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Loss of motivation and learning impairments are commonly accepted core symptoms of psychiatric disorders such as depression and schizophrenia. Reward-motivated learning is dependent on the hippocampal formation but the molecular mechanisms that lead to functional incentive motivation in this brain region are still largely unknown. Recent evidence implicates neurotransmission via metabotropic glutamate receptors and Homer1, their interaction partner in the postsynaptic density, in drug addiction and motivational learning. As previous reports mainly focused on the prefrontal cortex and the nucleus accumbens, we now investigated the role of hippocampal Homer1 in operant reward learning in the present study. We therefore tested either Homer1 knockout mice or mice that overexpress Homer1 in the hippocampus in an operant conditioning paradigm. Our results show that deletion of Homer1 leads to a diverging phenotype that either displays an inability to perform the task or outstanding hyperactivity in both learning and motivational sessions. Due to the apparent bimodal distribution of this phenotype, the overall effect of Homer1 deletion in this paradigm is not significantly altered. Overexpression of hippocampal Homer1 did not lead to a significantly altered learning performance in any stage of the testing paradigm, yet may subtly contribute to emerging motivational deficits. Our results indicate an involvement of Homer1-mediated signaling in the hippocampus in motivation-based learning tasks and encourage further investigations regarding the specific molecular underpinnings of the phenotypes observed in this study. We also suggest to cautiously interpret the results of this and other studies regarding the phenotype following Homer1 manipulations in animals, since their behavioral phenotype appears to be highly diverse. Future studies would benefit from larger group sizes that would allow splitting the experimental groups in responders and non-responders.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2014-01
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000330244500160
DOI: 10.1371/journal.pone.0085975
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: PLOS ONE
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 9 (1) Artikelnummer: e85975 Start- / Endseite: - Identifikator: ISSN: 1932-6203