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  Role of genetic variants in ADIPOQ in human eating behavior

Rohde, K., Keller, M., Horstmann, A., Liu, X., Eichelmann, F., Stumvoll, M., et al. (2015). Role of genetic variants in ADIPOQ in human eating behavior. Genes & Nutrition, 10(1): 1. doi:10.1007/s12263-014-0449-8.

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externe Referenz:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277552/ (beliebiger Volltext)
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 Urheber:
Rohde, Kerstin1, Autor
Keller, Maria1, Autor
Horstmann, Annette1, 2, Autor           
Liu, Xuanshi1, 3, Autor
Eichelmann, Fabian1, Autor
Stumvoll, Michael1, 4, Autor
Villringer, Arno2, 5, Autor           
Kovacs, Peter1, Autor
Tönjes, Anke4, Autor
Böttcher, Yvonne1, Autor
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Bioinformatics Group, Department of Computer Science, University of Leipzig, Germany, ou_persistent22              
4Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: Adiponectin serum levels; Genetics; Eating behavior; Human studies
 Zusammenfassung: The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eating. Here, we tested the hypothesis that (1) adiponectin serum levels correlate with human eating behavior factors and (2) that genetic variants of the ADIPOQ locus influence both serum levels and eating behavior. We analyzed 11 SNPs within ADIPOQ and in the 5' UTR and measured serum adiponectin levels in 1,036 individuals from the German Sorbs population. The German version of the three-factor eating questionnaire (FEV) was completed by 548 Sorbs. For replication purposes, we included an independent replication cohort from Germany (N = 350). In the Sorbs, we observed positive correlations of restraint with adiponectin serum levels (P = 0.001; r = 0.148) which, however, did not withstand adjustment for covariates (P = 0.083; r = 0.077). In addition, four SNPs were nominally associated with serum adiponectin levels (all P < 0.05). Of these, two variants (rs3774261; rs1501229, all P < 0.05) were also related to disinhibition. Furthermore, three variants were exclusively associated with hunger (rs2036373, P = 0.049) and disinhibition (rs822396; rs864265, all P < 0.05). However, none of these associations withstood Bonferroni corrections for multiple testing (all P > 9.3 × 10(-4)). In our replication cohort, we observed similar effect directions at rs1501229 for disinhibition and hunger. A meta-analysis resulted in nominal statistical significance P = 0.036 (Z score 2.086) and P = 0.017 (Z score 2.366), respectively. Given the observed relationship of the SNPs with adiponectin levels and eating behavior, our data support a potential role of adiponectin in human eating behavior. Whether the relationship with eating behavior is mediated by the effects of circulating adiponectin warrants further investigations.

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Sprache(n): eng - English
 Datum: 2014-11-282014-12-272015-01
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1007/s12263-014-0449-8
 Art des Abschluß: -

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Titel: Genes & Nutrition
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Berlin, Germany : Springer
Seiten: - Band / Heft: 10 (1) Artikelnummer: 1 Start- / Endseite: - Identifikator: ISSN: 1865-3499
CoNE: https://pure.mpg.de/cone/journals/resource/1865-3499