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  The Inner Structure of Human Otoconia

Walther, L. E., Blödow, A., Bloching, M. B., Buder, J., Carrillo-Cabrera, W., Roseeva, E., et al. (2014). The Inner Structure of Human Otoconia. Otology & Neurology, 35(4), 686-694. doi:10.1097/MAO.0000000000000206.

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Walther, Leif Erik1, Autor
Blödow, Alexander1, Autor
Bloching, Marc Boris1, Autor
Buder, Jana2, Autor           
Carrillo-Cabrera, Wilder3, Autor           
Roseeva, Elena4, Autor           
Borrmann, Horst5, Autor           
Simon, Paul6, Autor           
Kniep, Rüdiger7, Autor           
Affiliations:
1external, ou_persistent22              
2Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863425              
3Chemical Metal Science, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863405              
4Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863404              
5Horst Borrmann, Chemical Metal Science, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863410              
6Paul Simon, Chemical Metal Science, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863418              
7Rüdiger Kniep, Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863437              

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 Zusammenfassung: BACKGROUND: The architecture of human otoconia has been only poorly understood up to now. Currently, it is assumed that otoconia contain a central core surrounded by a shell. OBJECTIVES: To investigate the inner structure of human otoconia. METHODS: Human otoconia were investigated by environmental scanning electron microscopy (ESEM). The diffraction behavior was analyzed using X-ray techniques (XRD). Focused ion beam (FIB) slices of otoconia were investigated by transmission electron microscopy (TEM). The results were correlated with observations on degenerate human otoconia and decalcification experiments using ethylenediaminetetraacetic acid (EDTA). Artificial otoconia (calcite-gelatine and calcite-gelatine/agarose composites) were investigated in the same way and compared with human otoconia. RESULTS: Human otoconia represent highly mosaic-controlled calcite-based nanocomposites. The inner structure is composed of 3 + 3 branches with an ordered arrangement of nanocomposite particles and parallel orientation of fibrils. The surrounding belly is less ordered and appears more porous. Degenerate otoconia show a successive dissolution of the belly region exposing to the inner structure (branches) in later stages of degeneration. Artificial otoconia reveal identical chemical, crystallographic and morphologic patterns. They are, however, larger in size. CONCLUSION: Human otoconia show an inner architecture consisting of a less dense belly region and 3 + 3 more dense branches meeting at a central point (center of symmetry). The differences in volume densities and the resulting solubility may play a role in BPPV. Artificial otoconia may serve as a model for further investigations.

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 Datum: 2014-04-01
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1097/MAO.0000000000000206
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Titel: Otology & Neurology
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 35 (4) Artikelnummer: - Start- / Endseite: 686 - 694 Identifikator: CoNE: https://pure.mpg.de/cone/journals/resource/1531-7129