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Abstract:
Phosphorus nuclear magnetic resonance spectra of the Ha−ras oncogene product p21 and its nucleotide complexes have been obtained. It is shown that the 31P nuclear magnetic resonance spectra of a number of nucleotide−enzyme complexes show some common features. In particular, the chemical shift values of the −phosphorus resonance of enzyme−bound NTP and NDP (N=A,G) of hydrolases exhibit a downfield shift virtually identical for myosin, elongation factor Tu, and the Ha−ras oncogene product p21. This suggests that the stereochemistry around the −phosphorus might be similar in these compoun