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  Sequence and expression of a novel GABAA receptor alpha subunit

Ymer, S., Draguhn, A., Köhler, M., Schofield, P. R., & Seeburg, P. H. (1989). Sequence and expression of a novel GABAA receptor alpha subunit. FEBS Letters, 258(1), 119-122. doi:10.1016/0014-5793(89)81630-8.

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FEBSLett_258_1989_119.pdf (Any fulltext), 575KB
 
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 Creators:
Ymer, Sanie, Author
Draguhn, Andreas1, Author           
Köhler, Martin2, Author           
Schofield, Peter R., Author
Seeburg, Peter H.2, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: γ-Aminobutyric acid A receptor; Ligand-gated ion channel; Receptor subtype; Voltage clamp recording; cDNA cloning
 Abstract: Cloned cDNA encoding the bovine alpha 4 subunit of the GABAA receptor has been isolated. The predicted 51 amino acid long mature protein contains an exceptionally long intracellular domain and shares 53-56% sequence similarity to the previously characterized alpha 1, alpha 2 and alpha 3 subunits. Co-expression of alpha 4 and beta 1 in Xenopus oocytes resulted in the formation of GABA-gated chloride channels with expected pharmacology, although no benzodiazepine potentiation was observed. Northern analysis indicates that a 4 kb alpha 4 mRNA is expressed in the calf cerebellum, cortex and hippocampus but is barely detectable in the rat brain

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Language(s): eng - English
 Dates: 1989-08-091989-10-032001-11-121989-11-20
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 258 (1) Sequence Number: - Start / End Page: 119 - 122 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501