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  Current methods for inducing pluripotency in somatic cells

Tavernier, G., Mlody, B., Demeester, J., Adjaye, J., & De Smedt, S. C. (2013). Current methods for inducing pluripotency in somatic cells. Advanced Materials, 25(20), 2765-71. doi:10.1002/adma.201204874.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0018-F7AE-9 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0018-F7B0-1
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Tavernier.pdf (Verlagsversion), 222KB
 
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Tavernier.pdf
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Eingeschränkt (Max Planck Institute for Molecular Genetics, MBMG; )
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Copyright Datum:
2013
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© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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 Urheber:
Tavernier, G., Autor
Mlody, B.1, Autor           
Demeester, J., Autor
Adjaye, J.1, Autor           
De Smedt, S. C., Autor
Affiliations:
1Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479654              

Inhalt

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Schlagwörter: Animals Batch Cell Culture Techniques/*trends Cell Culture Techniques/*trends Genetic Engineering/*trends Humans Hybrid Cells/*cytology/*physiology Induced Pluripotent Stem Cells/*cytology/*physiology Tissue Engineering/trends
 Zusammenfassung: The groundbreaking discovery of reprogramming fibroblasts towards pluripotency merely by introducing four transcription factors (OCT4, SOX2, KLF4 and c-MYC) by means of retroviral transduction has created a promising revolution in the field of regenerative medicine. These so-called induced pluripotent stem cells (iPSCs) can provide a cell source for disease-modelling, drug-screening platforms, and transplantation strategies to treat incurable degenerative diseases, while circumventing the ethical issues and immune rejections associated with the use of non-autologous embryonic stem cells. The risk of insertional mutagenesis, caused both by the viral and transgene nature of the technique has proven to be the major limitation for iPSCs to be used in a clinical setting. In view of this, a variety of alternative techniques have been developed to induce pluripotency in somatic cells. This review provides an overview on current reprogramming protocols, discusses their pros and cons and future challenges to provide safe and transgene-free iPSCs.

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Sprache(n): eng - English
 Datum: 2012-11-272013-03-262013-05-28
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: 23529911
DOI: 10.1002/adma.201204874
ISSN: 1521-4095 (Electronic)0935-9648 (Linking)
URI: http://www.ncbi.nlm.nih.gov/pubmed/23529911http://onlinelibrary.wiley.com/store/10.1002/adma.201204874/asset/2765_ftp.pdf?v=1&t=htpn29do&s=44d56fa3766abcf95fc91d5591f2a6fc157bb733
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Titel: Advanced Materials
  Andere : Adv. Mater.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: [Deerfield Beach, FL : VCH Publishers]
Seiten: 7 Band / Heft: 25 (20) Artikelnummer: - Start- / Endseite: 2765 - 71 Identifikator: ISSN: 0935-9648
CoNE: https://pure.mpg.de/cone/journals/resource/954925570855