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Abstract:
Chromosome segregation is a complex and astonishingly accurate process
whose inner working is beginning to be understood at the molecular
level. The spindle checkpoint plays a key role in ensuring the fidelity
of this process. It monitors the interactions between chromosomes and
microtubules, and delays mitotic progression to allow extra time to
correct defects. Here, we review and integrate findings on the dynamics
of checkpoint proteins at kinetochores with structural information about
signalling complexes.
